NHS-PEG4-(m-PEG4)3-ester

Modify Date: 2024-01-08 18:55:23

NHS-PEG4-(m-PEG4)3-ester Structure
NHS-PEG4-(m-PEG4)3-ester structure
Common Name NHS-PEG4-(m-PEG4)3-ester
CAS Number 1333154-70-3 Molecular Weight 1363.539
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C60H110N6O28 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NHS-PEG4-(m-PEG4)3-ester


NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name NHS-PEG4-(m-PEG4)3-ester
Synonym More Synonyms

 NHS-PEG4-(m-PEG4)3-ester Biological Activity

Description NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C60H110N6O28
Molecular Weight 1363.539
Exact Mass 1362.736816
LogP -8.37
Index of Refraction 1.515

 Synonyms

4,11,14,17,20-Pentaoxa-7,23-diazaoctacosan-1-amide, 28-[(2,5-dioxo-1-pyrrolidinyl)oxy]-8,24,28-trioxo-6,6-bis(5-oxo-2,9,12,15,18-pentaoxa-6-azanonadec-1-yl)-N-3,6,9,12-tetraoxatridec-1-yl-
MFCD22683277
28-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-8,24,28-trioxo-6,6-bis(15-oxo-2,5,8,11,18-pentaoxa-14-azanonadecan-19-yl)-N-(2,5,8,11-tetraoxatridecan-13-yl)-4,11,14,17,20-pentaoxa-7,23-diazaoctacosan-1-amide
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