TC-S 7004
Modify Date: 2024-01-04 05:03:32
TC-S 7004 structure
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Common Name | TC-S 7004 | ||
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| CAS Number | 1386979-55-0 | Molecular Weight | 498.318 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H17Cl2N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC-S 7004Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68±48 nM and 22±8 nM respectively.IC50 value: 68±48/22±8 nM (Dyrk1B/Dyrk1A) [1]Target: Dyrk inhibitorMirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. At a much higher concentration of 10 mmol/L in a kinase assay, Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by88%, 64%, 56%, and 73%, respectively [1]. Mirk-IN-1 was able to block tumor cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2]. |
| Name | Mirk-IN-1 |
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| Synonym | More Synonyms |
| Description | Mirk-IN-1 is a potent inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A with IC50 of 68±48 nM and 22±8 nM respectively.IC50 value: 68±48/22±8 nM (Dyrk1B/Dyrk1A) [1]Target: Dyrk inhibitorMirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. At a much higher concentration of 10 mmol/L in a kinase assay, Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by88%, 64%, 56%, and 73%, respectively [1]. Mirk-IN-1 was able to block tumor cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C23H17Cl2N5O4 |
| Molecular Weight | 498.318 |
| Exact Mass | 497.065765 |
| LogP | 4.21 |
| Index of Refraction | 1.678 |
| Storage condition | 2-8℃ |
| N-{2-Chloro-5-[(3-chlorobenzyl)carbamoyl]phenyl}-2-methoxy-7-oxo-1,7-dihydropyrido[2,3-d]pyrimidine-6-carboxamide |
| Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[2-chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxo- |