TC-S 7009
Modify Date: 2024-01-05 14:43:14
TC-S 7009 structure
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Common Name | TC-S 7009 | ||
|---|---|---|---|---|
| CAS Number | 1422955-31-4 | Molecular Weight | 308.65200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H6ClFN4O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of TC-S 7009TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2]. |
| Name | N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine |
|---|---|
| Synonym | More Synonyms |
| Description | TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 81 nM (HIF-2α)[1] |
| In Vitro | TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment shows greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions[2]. TC-S 7009 (50 μM) treatment almost completely inhibits the hypoxia-induced NFATc2 nuclear translocation[2]. Cell Proliferation Assay[2] Cell Line: HPF cells in hypoxic conditions Concentration: 0-100 µM Incubation Time: 72 hours Result: Showed greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions. |
| References |
| Molecular Formula | C12H6ClFN4O3 |
|---|---|
| Molecular Weight | 308.65200 |
| Exact Mass | 308.01100 |
| PSA | 96.77000 |
| LogP | 4.26330 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H413 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| HIF2α-IN-2 |