TC-S 7006

Modify Date: 2024-02-05 17:03:31

TC-S 7006 Structure
TC-S 7006 structure
Common Name TC-S 7006
CAS Number 871307-18-5 Molecular Weight 404.82700
Density N/A Boiling Point N/A
Molecular Formula C21H14ClFN6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TC-S 7006


Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].

 Names

Name 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile
Synonym More Synonyms

 TC-S 7006 Biological Activity

Description Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].
Related Catalog
Target

MAP3K8

In Vitro Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[1].
References

[1]. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.

 Chemical & Physical Properties

Molecular Formula C21H14ClFN6
Molecular Weight 404.82700
Exact Mass 404.09500
PSA 86.52000
LogP 5.19068

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile
Tpl2 Kinase Inhibitor
4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE
4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
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