Amino-PEG1-C2-acid

Modify Date: 2024-01-13 14:23:37

Amino-PEG1-C2-acid Structure
Amino-PEG1-C2-acid structure
Common Name Amino-PEG1-C2-acid
CAS Number 144942-89-2 Molecular Weight 133.146
Density 1.1±0.1 g/cm3 Boiling Point 284.7±20.0 °C at 760 mmHg
Molecular Formula C5H11NO3 Melting Point N/A
MSDS N/A Flash Point 126.0±21.8 °C

 Use of Amino-PEG1-C2-acid


Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-(2-Aminoethoxy)propanoic acid
Synonym More Synonyms

 Amino-PEG1-C2-acid Biological Activity

Description Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 284.7±20.0 °C at 760 mmHg
Molecular Formula C5H11NO3
Molecular Weight 133.146
Flash Point 126.0±21.8 °C
Exact Mass 133.073898
LogP -0.85
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.466

 Synonyms

MFCD22017475
Propanoic acid, 3-(2-aminoethoxy)-
3-(2-Aminoethoxy)propanoic acid
Amino-PEG1-acid
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