Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI)

Modify Date: 2024-01-10 18:58:31

Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI) Structure
Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI) structure
Common Name Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI)
CAS Number 15049-50-0 Molecular Weight 572.59
Density 1.45g/cm3 Boiling Point N/A
Molecular Formula C30H24N2O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI)


2’,3’,5’-Tri-O-benzoyl-4-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name [3,4-dibenzoyloxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl benzoate
Synonym More Synonyms

  Biological Activity

Description 2’,3’,5’-Tri-O-benzoyl-4-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.45g/cm3
Molecular Formula C30H24N2O8S
Molecular Weight 572.59
Exact Mass 572.12500
PSA 158.01000
LogP 4.11150
Index of Refraction 1.686

 Synthetic Route

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Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI) Structure

Uridine,4-thio-...

CAS#:15049-50-0

Literature: Xu, Yao-Zhong; Zheng, Qinguo; Swann, Peter F. Tetrahedron Letters, 1991 , vol. 32, # 24 p. 2817 - 2820

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Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI) Structure

Uridine,4-thio-...

CAS#:15049-50-0

Literature: Fox et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 178,187

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Uridine,4-thio-, 2',3',5'-tribenzoate (6CI,7CI,8CI,9CI) Structure

Uridine,4-thio-...

CAS#:15049-50-0

Literature: Fox et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 178,187

 Synonyms

O2',O3',O5'-Tribenzoyl-4-thio-uridin
2',3',5'-tribenzoyl 4-thiouridine
2',3',5'-Tri-O-benzoyl-4-thio-uridin
O2',O3',O5'-tribenzoyl-4-thio-uridine
2',3',5'-tri-O-benzoyl-4-thiouridine