Methylamino-PEG2-Boc

Modify Date: 2024-01-11 21:54:46

Methylamino-PEG2-Boc Structure
Methylamino-PEG2-Boc structure
Common Name Methylamino-PEG2-Boc
CAS Number 1807521-04-5 Molecular Weight 247.331
Density 1.0±0.1 g/cm3 Boiling Point 315.5±22.0 °C at 760 mmHg
Molecular Formula C12H25NO4 Melting Point N/A
MSDS N/A Flash Point 144.6±22.3 °C

 Use of Methylamino-PEG2-Boc


Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 3-{2-[2-(methylamino)ethoxy]ethoxy}propanoate
Synonym More Synonyms

 Methylamino-PEG2-Boc Biological Activity

Description Methylamino-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 315.5±22.0 °C at 760 mmHg
Molecular Formula C12H25NO4
Molecular Weight 247.331
Flash Point 144.6±22.3 °C
Exact Mass 247.178360
LogP 0.79
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.441

 Synonyms

2-Methyl-2-propanyl 3-{2-[2-(methylamino)ethoxy]ethoxy}propanoate
Propanoic acid, 3-[2-[2-(methylamino)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD28155207
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