Tat-NR2B9c TFA

Modify Date: 2024-01-16 16:35:04

Tat-NR2B9c TFA structure	Common Name	Tat-NR2B9c TFA
	CAS Number	1834571-04-8	Molecular Weight	2632.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀₇H₁₈₉F₃N₄₂O₃₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tat-NR2B9c TFA

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].

Name	Tat-NR2B9c TFA

Description	Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Neurological Disease
Target	EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1] p38[2]
References	[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.

Molecular Formula	C₁₀₇H₁₈₉F₃N₄₂O₃₂
Molecular Weight	2632.90
Storage condition	2-8℃

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tat-NR2B9cTFA
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Purity: 98.0%
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