TH 1217
Modify Date: 2024-01-14 19:28:02
TH 1217 structure
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Common Name | TH 1217 | ||
|---|---|---|---|---|
| CAS Number | 1862212-48-3 | Molecular Weight | 491.09 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H17BCl2N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TH 1217TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. |
| Name | TH1217 |
|---|
| Description | TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. |
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| Related Catalog | |
| Target |
IC50: 47 nM (dCTPase)[1] |
| In Vitro | TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%)[1]. TH1217 presents suitable mouse microsomal half-lives (109 minutes)[1]. TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition[1]. |
| References |
| Molecular Formula | C20H17BCl2N4O6 |
|---|---|
| Molecular Weight | 491.09 |
| Storage condition | -20°C |