GPI-1485
Modify Date: 2024-01-11 17:55:45
GPI-1485 structure
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Common Name | GPI-1485 | ||
|---|---|---|---|---|
| CAS Number | 186268-78-0 | Molecular Weight | 241.28400 | |
| Density | 1.189 g/cm3 | Boiling Point | 386.198ºC at 760 mmHg | |
| Molecular Formula | C12H19NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 187.366ºC | |
Use of GPI-1485GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1]. |
| Name | (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylic acid |
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| Synonym | More Synonyms |
| Description | GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1]. |
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| Related Catalog | |
| In Vitro | GPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF)[1]. Cell Viability Assay[1] Cell Line: Normal human dermal fibroblasts (NHDF)[1] Concentration: 100 μM Incubation Time: Result: Induced cellular reprogramming and neural cell induction. |
| In Vivo | GPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats[1]. Animal Model: Adult male Wistar rats, weighing 250-300 g[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily; for a total of 42 days Result: Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats. |
| References |
| Density | 1.189 g/cm3 |
|---|---|
| Boiling Point | 386.198ºC at 760 mmHg |
| Molecular Formula | C12H19NO4 |
| Molecular Weight | 241.28400 |
| Flash Point | 187.366ºC |
| Exact Mass | 241.13100 |
| PSA | 74.68000 |
| LogP | 1.00520 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2933990090 |
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~89%
GPI-1485 CAS#:186268-78-0 |
| Literature: GPI Nil Holdings Inc. Patent: US7410995 B1, 2008 ; Location in patent: Page/Page column 29 ; |
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GPI-1485 CAS#:186268-78-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557 |
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GPI-1485 CAS#:186268-78-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 55, # 9 p. 4114 - 4122 |
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| (S)-methyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate |
| UNII-0709BVY57W |
| (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidincarboxylic acid |
| GPI-1485 |
| (2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidine-carboxylic acid |