α-Conotoxin AuIB TFA

Modify Date: 2024-01-02 19:47:42

α-Conotoxin AuIB TFA Structure
α-Conotoxin AuIB TFA structure
Common Name α-Conotoxin AuIB TFA
CAS Number 216299-21-7 Molecular Weight 1572.76000
Density N/A Boiling Point N/A
Molecular Formula C65H89N17O21S4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-Conotoxin AuIB TFA


α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM[1].

 Names

Name α-Conotoxin AuIB
Synonym More Synonyms

 α-Conotoxin AuIB TFA Biological Activity

Description α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM[1].
Related Catalog
Target

IC50: 0.75 μM (α3β4 nAChR; in Xenopus oocytes)[1]

In Vitro α-Conotoxin AuIB blocks the α3β4 receptor with >100-fold higher potency than other receptor subunit combinations, including α2β2, α2β4, α3β2, α4β2, α4β4, and α1β1γδ[1].
References

[1]. Siqin Luo, et al. α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release.Journal of Neuroscience. 1998 Nov 1, 18 (21): 8571-8579.

 Chemical & Physical Properties

Molecular Formula C65H89N17O21S4
Molecular Weight 1572.76000
Exact Mass 1571.53000
PSA 692.42000

 Safety Information

Hazard Codes T+

 Synonyms

A-CONOTOXIN AUIB
AuIB globular
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