MEK/PI3K-IN-1 structure
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Common Name | MEK/PI3K-IN-1 | ||
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CAS Number | 2281803-28-7 | Molecular Weight | 913.63 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C36H37F5IN9O6 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of MEK/PI3K-IN-1MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1]. |
Name | MEK/PI3K-IN-1 |
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Description | MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1]. |
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Related Catalog | |
Target |
MEK1:124 ± 11 nM (IC50) PI3Kα:130 ± 13 nM (IC50) PI3Kδ:236 ± 29 nM (IC50) PI3Kβ:1537 ± 188 nM (IC50) PI3Kγ:2745 ± 485 nM (IC50) |
References |
Molecular Formula | C36H37F5IN9O6 |
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Molecular Weight | 913.63 |