DNA Gyrase-IN-5

Modify Date: 2024-01-11 09:54:52

DNA Gyrase-IN-5 structure	Common Name	DNA Gyrase-IN-5
	CAS Number	2417016-23-8	Molecular Weight	500.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₁₅BrClN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DNA Gyrase-IN-5

DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains[1].

Name	DNA Gyrase-IN-5

Description	DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.10 μM (DNA gyrase)[1]
In Vitro	DNA Gyrase-IN-5 (Compound 8I-w) shows antibacterial activities with IC50 values of 4.7, 7.0, 17.0, 13.5, 1.0, 25.3 and 47.8 μM against E. coli, E. coli E564, E. coli E68, E. coli E48, E. coli E109, Salmonella and S. aureus, respectively[1].
References	[1]. Liu H, et al. Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase. Bioorg Chem. 2020 Jun;99:103807.

Molecular Formula	C₂₅H₁₅BrClN₅
Molecular Weight	500.78