Thalidomide-NH-PEG7

Modify Date: 2024-01-11 11:58:33

Thalidomide-NH-PEG7 Structure
Thalidomide-NH-PEG7 structure
Common Name Thalidomide-NH-PEG7
CAS Number 2641838-98-2 Molecular Weight 581.61
Density N/A Boiling Point N/A
Molecular Formula C27H39N3O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-NH-PEG7


Thalidomide-NH-PEG7 is a synthesized E3 ligase ligand-linker conjugate for ADC. Thalidomide-NH-PEG7 can be connected to the ligand for protein by a linker to form PROTAC iRucaparib-AP6, a highly specific PARP1 degrader[1].

 Names

Name Thalidomide-NH-PEG7

 Thalidomide-NH-PEG7 Biological Activity

Description Thalidomide-NH-PEG7 is a synthesized E3 ligase ligand-linker conjugate for ADC. Thalidomide-NH-PEG7 can be connected to the ligand for protein by a linker to form PROTAC iRucaparib-AP6, a highly specific PARP1 degrader[1].
Related Catalog
Target

Cereblon

References

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.

 Chemical & Physical Properties

Molecular Formula C27H39N3O11
Molecular Weight 581.61

 Safety Information

Hazard Codes Xi