Negletein

Modify Date: 2024-01-09 13:11:21

Negletein Structure
Negletein structure
 Common Name Negletein
CAS Number 29550-13-8 Molecular Weight 284.26300
Density 1.42g/cm3 Boiling Point 541.1ºC at 760mmHg
Molecular Formula C16H12O5 Melting Point 218-220ºC
MSDS N/A Flash Point 207.5ºC

 Use of Negletein


Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively[1].

 Names

Name 5,6-dihydroxy-7-methoxyflavone
Synonym More Synonyms

 Negletein Biological Activity

Description Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively[1].
Related Catalog
References

[1]. Phan CW, et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599.

[2]. Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.

 Chemical & Physical Properties

Density 1.42g/cm3
Boiling Point 541.1ºC at 760mmHg
Melting Point 218-220ºC
Molecular Formula C16H12O5
Molecular Weight 284.26300
Flash Point 207.5ºC
Exact Mass 284.06800
PSA 79.90000
LogP 2.87980
Vapour Pressure 2.54E-12mmHg at 25°C
Index of Refraction 1.668
Storage condition 2-8℃

 Safety Information

Risk Phrases R36/37/38
Safety Phrases S26-S36
HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

BAICALEIN-7-METHYL ETHER
7-O-Methylbaicalein
5,6-dihydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
5,6-dihydroxy-7-methoxy-2-phenyl-4H-chromen-4-one
BAICALEIN METHYL ETHER
NEGLETEIN
5,6-dihydroxy-7-methoxy-2-phenyl-chromen-4-one
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