LSD1-IN-24

Modify Date: 2024-02-01 10:28:10

LSD1-IN-24 Structure
LSD1-IN-24 structure
Common Name LSD1-IN-24
CAS Number 4734-59-2 Molecular Weight 312.43
Density N/A Boiling Point N/A
Molecular Formula C18H20N2OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LSD1-IN-24


LSD1-IN-24(compound 3S) is a selective LSD1 inhibitor with IC50 = 0.247 μM. LSD1-IN-24 can mediate the expression of PD-L1, enhance T cell killing response, and can be used in cancer research[1].

 Names

Name LSD1-IN-24

 LSD1-IN-24 Biological Activity

Description LSD1-IN-24(compound 3S) is a selective LSD1 inhibitor with IC50 = 0.247 μM. LSD1-IN-24 can mediate the expression of PD-L1, enhance T cell killing response, and can be used in cancer research[1].
Related Catalog
In Vitro LSD1-IN-24 (compound 3S)(0-20 μM, 5 days) 可以以 LSD1 依赖性方式降低 PD-L1 水平并以剂量依赖性方式增强 BGC-823 细胞的 T 细胞杀伤反应,但不影响 BGC-823 和 MFC 细胞增殖。此外,它可以剂量依赖性地保护 H3K4me1/2 免于去甲基化,但不能保护 H3K4me3[1]。
In Vivo LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) 在含 MFC 细胞的皮下肿瘤模型中,以剂量依赖的方式抑制体内 MFC 细胞的生长,肿瘤的重量明显下降,肿瘤组织 Ki67 明显降低,并且对小鼠无明显毒性作用[1]。 Animal Model: Male 615 mice with MFC cell[1] Dosage: 0, 10, 25, and 50 mg/kg Administration: Oral gavage; daily for 2 weeks Result: Significantly decreased intratumoral PD-L1 expression, increased CD3+, CD4+, CD8+ cell numbers, interleukin-2 (IL2) and IFNγ mRNA and protein levels were also upregulated.
References

[1]. Xing-Jie Dai, et al. Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells. J Med Chem. 2023 Mar 23;66(6):3896-3916.   

 Chemical & Physical Properties

Molecular Formula C18H20N2OS
Molecular Weight 312.43