TC OT 39
Modify Date: 2024-07-16 13:04:08
TC OT 39 structure
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Common Name | TC OT 39 | ||
|---|---|---|---|---|
| CAS Number | 479232-57-0 | Molecular Weight | 600.777 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C32H40N8O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC OT 39TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models[1]. |
| Name | TC OT 39 |
|---|---|
| Synonym | More Synonyms |
| Description | TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models[1]. |
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| Related Catalog | |
| Target |
Avprla vasopressin receptor:300 nM (Ki) Oxytocin Receptor:180 nM (EC50) |
| In Vivo | TC OT 39 (50 mg/kg、75 mg/kg；腹腔注射；在 8-9 天内注射 4 次)，在 50 mg/kg 的剂量下，显著减少 C57BL/6J 小鼠的大理石掩埋行为，并在 75 mg/kg 的剂量下显示出明显的镇静作用[1]。 大理石掩埋是基于啮齿动物掩埋物体的自然本能，常用于临床前研究以评估啮齿动物的焦虑样行为[1]。 |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C32H40N8O2S |
| Molecular Weight | 600.777 |
| Exact Mass | 600.299500 |
| LogP | 2.00 |
| Index of Refraction | 1.702 |
| (2S)-2-[(4-Methyl-1,4-diazepan-1-yl)carbonothioyl]-N-{2-methyl-4-[(1-methyl-4,10-dihydropyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]benzyl}-1-pyrrolidinecarboxamide |
| (2S)-2-[(4-methyl-1,4-diazepan-1-yl)carbothioyl]-N-{2-methyl-4-[(1-methyl-4,10-dihydropyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]benzyl}pyrrolidine-1-carboxamide |
| 1-Pyrrolidinecarboxamide, N-[[4-[(4,10-dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-, (2S)- |
| MFCD28133368 |
| TC OT 39 |