6-(Furfurylamino)purine

Modify Date: 2024-01-02 23:25:40

6-(Furfurylamino)purine Structure
6-(Furfurylamino)purine structure
 Common Name 6-(Furfurylamino)purine
CAS Number 525-79-1 Molecular Weight 215.211
Density 1.6±0.1 g/cm3 Boiling Point 367.6±52.0 °C at 760 mmHg
Molecular Formula C10H9N5O Melting Point 269-271 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 176.1±30.7 °C

 Use of 6-(Furfurylamino)purine


Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes.IC50 Value: Target:Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4].

 Names

Name kinetin
Synonym More Synonyms

 6-(Furfurylamino)purine Biological Activity

Description Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes.IC50 Value: Target:Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4].
Related Catalog
References

[1]. Kunikowska A, et al. Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings. Protoplasma. 2013 Aug;250(4):851-61.

[2]. Axelrod FB, et al. Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia. Pediatr Res. 2011 Nov;70(5):480-3.

[3]. Hims MM, et al. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb;85(2):149-61.

[4]. Griffaut B, et al. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004 Aug;34(4):271-5.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 367.6±52.0 °C at 760 mmHg
Melting Point 269-271 °C (dec.)(lit.)
Molecular Formula C10H9N5O
Molecular Weight 215.211
Flash Point 176.1±30.7 °C
Exact Mass 215.080704
PSA 79.63000
LogP -0.56
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.774
Storage condition −20°C
Water Solubility H2O: soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU6270000
CHEMICAL NAME :
Adenine, N-furfuryl-
CAS REGISTRY NUMBER :
525-79-1
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C10-H9-N5-O
MOLECULAR WEIGHT :
215.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Leukocyte
DOSE/DURATION :
100 umol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases 68-36/37/38
Safety Phrases S23-S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AU6270000
HS Code 29349990

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles47

More Articles
Cloning and Expression of TNF Related Apoptosis Inducing Ligand in Nicotiana tabacum.

Iran. J. Pharm. Res. 14(1) , 189-201, (2015)

Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical can...

Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.

Biomed Res. Int. 2015 , 708691, (2015)

Nigella sativa L. (family Ranunculaceae) is an annual herb of immense medicinal properties because of its major active components (i.e., thymoquinone (TQ), thymohydroquinone (THQ), and thymol (THY)). ...

[Study on optimization of induction system of test-tube tuberous roots from leaves of Rehmannia glutinosa].

Zhongguo Zhong Yao Za Zhi 37(24) , 3812-4, (2012)

To study the effect of sucrose and plant growth substances of different concentrations on the induction of test-tube tuberous roots of Rehmannia glutinosa, in order to establish an efficient system fo...

 Synonyms

6-Furfurylaminopurine,N6-Furfuryladenine
N-(2-Furylmethyl)-7H-purin-6-amine
N-furfuryl-7H-purin-6-amine
N-(2-Furylmethyl)-3H-purin-6-amine
N-(Furan-2-ylmethyl)-1H-purin-6-amine
MFCD00075757
7H-Purin-6-amine, N-(2-furanylmethyl)-
T56 BM DN FN HNJ IM1- BT5OJ
cytokinin
fap
EINECS 208-382-2
N-(2-furanylmethyl)-1H-purin-6-amine
QUINETINE
6-(Furfurylamino)purine
Kinetin
N-Furfuryl-Adenine
Kiniten
N6-Furfuryladenine
N-(Furan-2-ylmethyl)-9H-purin-6-amine
3H-Purin-6-amine, N-(2-furanylmethyl)-
6-Furfurylaminopurine
KINETINE
N6-(2-Furylmethyl)-9H-purin-6-amine
N(Sup6)-Furfuryladenine
N-(furan-2-ylmethyl)-7H-purin-6-amine
Adenine, N-furfuryl-
N-Furfuryladenine
Kinetina
T56 BM DN GN INJ FM1- BT5OJ
Top Suppliers:I want be here

Get all suppliers and price by the below link:

6-(Furfurylamino)purine suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more 6-(Furfurylamino)purine price

Related Compounds: More...
6-furfurylamino-1,3-dimethyl-1H-pyrimidine-2,4-dione
100128-16-3
2-amino-6-(2-furylmethylamino)-1H-pyrimidin-4-one
6944-09-8
9H-Purin-6-amine, N-(2-furanylmethyl)-9-β-D-glucopyranosyl
98177-43-6
9-(2-furylmethyl)-N-(4-methoxyphenyl)purin-6-amine
17946-48-4
2-Aminopurine
452-06-2
2-[cyclohexyl-(3,4-dimethoxyphenyl)sulfonyl-amino]-N-[(4-methylphenyl)methyl]acetamide
6332-15-6
6-(phenyldithio)purine
2958-91-0
6-(Methylthio)purine
50-66-8
6-(octadecylthio)purine
122714-66-3
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
(2S)-4-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyridin-2-yl]formamido}-2-hydroxybutanoic acid
2171185-36-5
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
3-[1-(Hydroxymethyl)-3,5-dimethylcyclohexyl]-1-methylpyrrolidin-3-ol
2172093-56-8
tert-Butyl-DL-alanine
1375289-11-4
Chemsrc provides 6-(Furfurylamino)purine(CAS#:525-79-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 6-(Furfurylamino)purine are included as well.>> amp version: 6-(Furfurylamino)purine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved