6-(Furfurylamino)purine

Modify Date: 2024-01-02 23:25:40

6-(Furfurylamino)purine structure	Common Name	6-(Furfurylamino)purine
	CAS Number	525-79-1	Molecular Weight	215.211
	Density	1.6±0.1 g/cm3	Boiling Point	367.6±52.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₉N₅O	Melting Point	269-271 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	176.1±30.7 °C

Use of 6-(Furfurylamino)purine

Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes.IC50 Value: Target:Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4].

Name	kinetin
Synonym	More Synonyms

Description	Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes.IC50 Value: Target:Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4].
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Kunikowska A, et al. Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings. Protoplasma. 2013 Aug;250(4):851-61. [2]. Axelrod FB, et al. Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia. Pediatr Res. 2011 Nov;70(5):480-3. [3]. Hims MM, et al. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb;85(2):149-61. [4]. Griffaut B, et al. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004 Aug;34(4):271-5.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

References

[1]. Kunikowska A, et al. Kinetin induces cell death in root cortex cells of Vicia faba ssp. minor seedlings. Protoplasma. 2013 Aug;250(4):851-61.

[2]. Axelrod FB, et al. Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia. Pediatr Res. 2011 Nov;70(5):480-3.

[3]. Hims MM, et al. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb;85(2):149-61.

[4]. Griffaut B, et al. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004 Aug;34(4):271-5.

Density	1.6±0.1 g/cm3
Boiling Point	367.6±52.0 °C at 760 mmHg
Melting Point	269-271 °C (dec.)(lit.)
Molecular Formula	C₁₀H₉N₅O
Molecular Weight	215.211
Flash Point	176.1±30.7 °C
Exact Mass	215.080704
PSA	79.63000
LogP	-0.56
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.774
Storage condition	−20°C
Water Solubility	H2O: soluble

6-(Furfurylamino)purine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6270000

CHEMICAL NAME :: Adenine, N-furfuryl-

CAS REGISTRY NUMBER :: 525-79-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H9-N5-O

MOLECULAR WEIGHT :: 215.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	68-36/37/38
Safety Phrases	S23-S24/25-S22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU6270000
HS Code	29349990

Precursor 9
CAS#:98-01-1 Furfural CAS#:66224-66-6 6H-Purin-6-imin... CAS#:617-89-0 Furfurylamine CAS#:56025-87-7 7-benzyl-2,6-di...
CAS#:68-94-0 Hypoxanthine CAS#:19769-32-5 6-methylsulfony... CAS#:50-66-8 6-(Methylthio)purine CAS#:98-00-0 Furfuryl alcohol
CAS#:7387-58-8 [5-(6-acetamido...
DownStream 8
CAS#:109403-64-7 N-(2-Furanylmet... CAS#:4338-47-0 Kinetin riboside CAS#:98-00-0 Furfuryl alcohol CAS#:617-89-0 Furfurylamine
CAS#:68-94-0 Hypoxanthine CAS#:124-20-9 spermidine CAS#:71-44-3 Spermine CAS#:110-60-1 putrescine

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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6-Furfurylaminopurine,N6-Furfuryladenine

N-(2-Furylmethyl)-7H-purin-6-amine

N-furfuryl-7H-purin-6-amine

N-(2-Furylmethyl)-3H-purin-6-amine

N-(Furan-2-ylmethyl)-1H-purin-6-amine

MFCD00075757

7H-Purin-6-amine, N-(2-furanylmethyl)-

T56 BM DN FN HNJ IM1- BT5OJ

cytokinin

fap

EINECS 208-382-2

N-(2-furanylmethyl)-1H-purin-6-amine

QUINETINE

6-(Furfurylamino)purine

Kinetin

N-Furfuryl-Adenine

Kiniten

N6-Furfuryladenine

N-(Furan-2-ylmethyl)-9H-purin-6-amine

3H-Purin-6-amine, N-(2-furanylmethyl)-

6-Furfurylaminopurine

KINETINE

N6-(2-Furylmethyl)-9H-purin-6-amine

N(Sup6)-Furfuryladenine

N-(furan-2-ylmethyl)-7H-purin-6-amine

Adenine, N-furfuryl-

N-Furfuryladenine

Kinetina

T56 BM DN GN INJ FM1- BT5OJ

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China
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China
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China
Product Name: 6-(Furfurylamino)purine
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China
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China
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China
Product Name: Kinetin
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: kinetin
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6-(Furfurylamino)purine

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