Euxanthone
Modify Date: 2024-01-02 14:58:41
Euxanthone structure
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Common Name | Euxanthone | ||
|---|---|---|---|---|
| CAS Number | 529-61-3 | Molecular Weight | 228.200 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 472.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H8O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 191.1±22.2 °C | |
Use of EuxanthoneEuxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
| Name | euxanthone |
|---|---|
| Synonym | More Synonyms |
| Description | Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
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| Related Catalog | |
| In Vitro | Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。 Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Inhibited cell migration at 24 hr. Western Blot Analysis[1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion. |
| In Vivo | 在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] Dosage: 30 mg/kg, 60 mg/kg Administration: p.o.;once a day; for 7 days Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 472.6±45.0 °C at 760 mmHg |
| Molecular Formula | C13H8O4 |
| Molecular Weight | 228.200 |
| Flash Point | 191.1±22.2 °C |
| Exact Mass | 228.042252 |
| PSA | 70.67000 |
| LogP | 1.92 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.718 |
| HS Code | 2932999099 |
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| Precursor 10 | |
|---|---|
| DownStream 6 | |
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CAS#:144-62-7![1-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one structure](https://image.chemsrc.com/caspic/166/96935-32-9.png)
CAS#:96935-32-9| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1,7-Dihydroxy-9H-xanthen-9-one |
| 1,7-dihydroxyxanthen-9-one |
| purrenone |
| 1,7-Dihydroxyxanthone |
| eyxanthone |
| Euxanthone |
| 1,7-Dihydroxy-xanthen-9-on |
| 1,7-dihydroxy-xanthen-9-one |
| 9H-Xanthen-9-one, 1,7-dihydroxy- |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Euxanthone
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: Euxanthone
- Price: ￥2500.0/5mg
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Xueping-Zheng
- Email: 1477035482@qq.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Euxanthone
- Price: ￥3520.0/5mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1,7-DIHYDROXY-9H-XANTHEN-9-ONE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: ￥5616/5mg
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