Sucralose

Modify Date: 2024-01-02 09:19:35

Sucralose Structure
Sucralose structure
 Common Name Sucralose
CAS Number 56038-13-2 Molecular Weight 397.634
Density 1.7±0.1 g/cm3 Boiling Point 669.4±55.0 °C at 760 mmHg
Molecular Formula C12H19Cl3O8 Melting Point 125.5ºC
MSDS Chinese USA Flash Point 358.7±31.5 °C

 Use of Sucralose


Sucralose is an intense organochlorine artificial sweetener.

 Names

Name sucralose
Synonym More Synonyms

 Sucralose Biological Activity

Description Sucralose is an intense organochlorine artificial sweetener.
Related Catalog
In Vivo The results show that Sucralose induces significant increased incidence of all hematopoietic neoplasias in male mice exposed to 2,000 (p≤0.01), and 16,000 ppm (p≤0.01), with a significant dose-related relationship (p≤0.01). Microscopically, most of the neoplasias among male mice treated with Sucralose at 2,000 to 16,000 ppm are leukemias involving lungs, liver, spleen, lymph nodes, and bone marrow with diffuse permeation of vessels and extensive infiltration of adjacent tissues[1].
Animal Admin Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].
References

[1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 669.4±55.0 °C at 760 mmHg
Melting Point 125.5ºC
Molecular Formula C12H19Cl3O8
Molecular Weight 397.634
Flash Point 358.7±31.5 °C
Exact Mass 396.014557
PSA 128.84000
LogP 0.68
Vapour Pressure 0.0±4.6 mmHg at 25°C
Index of Refraction 1.604
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LW5440140
CHEMICAL NAME :
alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-
CAS REGISTRY NUMBER :
56038-13-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H19-Cl3-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>16 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TBSCDB Trends in Biochemical Sciences. (Elsevier Science Publishing Co., Inc., 655 Avenue of the Americas, New York, NY 10010) V.1- 1976- Volume(issue)/page/year: 3,61,1978

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-37/39
RIDADR NONH for all modes of transport
RTECS LW5440140
HS Code 2932999099

 Synthetic Route

4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acetate structure

4,1',6'-trichlo...

CAS#:105066-21-5

~96%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: Wu, Jun Jing; Wu, Guang Li; Cai, Qing Hai; Xinyu, Shou; Li, Zi Wen; Liu, Shang; Wang, Man Tang Patent: US2008/58508 A1, 2008 ; Location in patent: Page/Page column 3 ;
3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactose, triacetate structure

3,4-di-O-acetyl...

CAS#:55832-20-7

~85%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: EMCURE PHARMACEUTICALS LIMITED Patent: WO2007/96726 A2, 2007 ; Location in patent: Page/Page column 32 ;
Sucrose-6-acetic ester structure

Sucrose-6-aceti...

CAS#:63648-81-7

~70%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: TATE and LYLE TECHNOLOGY LIMITED; WILEY, James, Edwin; JABER, Mohamad, R. Patent: WO2010/151489 A1, 2010 ; Location in patent: Page/Page column 14 ;
sucrose 4-acetate structure

sucrose 4-acetate

CAS#:63648-78-2

~48%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: PHARMED MEDICARE PVT. LTD. Patent: US2009/118493 A1, 2009 ; Location in patent: Page/Page column 3 ;
6-acetyl sucrose structure

6-acetyl sucrose

CAS#:63648-85-1

~%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: US2010/56773 A1, ; Page/Page column 2 ;
Sucrose-6-acetic ester structure

Sucrose-6-aceti...

CAS#:63648-81-7

~%

4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acetate structure

4,1',6'-trichlo...

CAS#:105066-21-5

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: US2010/160625 A1, ; Page/Page column 2 ;
1,1,1-Trimethoxyethane structure

1,1,1-Trimethox...

CAS#:1445-45-0

p-Toluenesulfonic acid structure

p-Toluenesulfon...

CAS#:104-15-4

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

sucrose structure

sucrose

CAS#:57-50-1

~%

Detail
Literature: EP260979 B1, ;
D-Mannitol structure

D-Mannitol

CAS#:69-65-8

~%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Literature: US2011/64812 A1, ;

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles50

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 Synonyms

(2R,3R,4R,5R,6R)-2-{[(2R,3S,4S,5S)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydro-2-furanyl]oxy}-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol
1',4,6'-Trichlorogalactosucrose
1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside
a-D-galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy-
trichlorosucrose
(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
MFCD03648615
1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy-a-D-galactopyranoside
Sucralose
EINECS 259-952-2
1,6-Dichlor-1,6-dideoxy-β-D-fructofuranosyl-4-chlor-4-deoxy-α-D-galactopyranoside
4,1',6'-Trichloro-4,1',6'-trideoxygalacto-sucrose
1,6-Dichloro-1,6-dideoxy-b-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside
splenda
α-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-
UNII-96K6UQ3ZD4
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