D-Mannitol

Modify Date: 2024-01-02 13:58:30

D-Mannitol structure	Common Name	D-Mannitol
	CAS Number	69-65-8	Molecular Weight	182.172
	Density	1.6±0.1 g/cm3	Boiling Point	494.9±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₄O₆	Melting Point	167-170ºC
	MSDS	Chinese USA	Flash Point	292.5±23.3 °C

Use of D-Mannitol

D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.Target: OthersD(-)Mannitol is a sugar alcohol that can be used as an inert osmotic control substance. The uptake and phosphorylation of d-mannitol is catalyzed by the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase systems (PTS). Mannitol can interact with neutrophils and monocytes. Experiments have shown that it is able to decrease neutrophil apoptosis in vitro. The compound has been used in studies as a stimulator of cecal microbial growth and cellulolytic activity in rabbits. It has been observed that mannitol can lower the fat digestibility and body fat accumulation in both normal and cecectomized rats, as well as upregulate monocyte HLA-DR, monocyte and neutrophil CD11b. Studies show that the mannitol operon is repressed by the transcription factor, mannitol operon repressor (MtlR) in Escherichia coli [1-3].

Name	D-mannitol
Synonym	More Synonyms

Description	D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.Target: OthersD(-)Mannitol is a sugar alcohol that can be used as an inert osmotic control substance. The uptake and phosphorylation of d-mannitol is catalyzed by the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase systems (PTS). Mannitol can interact with neutrophils and monocytes. Experiments have shown that it is able to decrease neutrophil apoptosis in vitro. The compound has been used in studies as a stimulator of cecal microbial growth and cellulolytic activity in rabbits. It has been observed that mannitol can lower the fat digestibility and body fat accumulation in both normal and cecectomized rats, as well as upregulate monocyte HLA-DR, monocyte and neutrophil CD11b. Studies show that the mannitol operon is repressed by the transcription factor, mannitol operon repressor (MtlR) in Escherichia coli [1-3].
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
References	[1]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9. [2]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51. [3]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.

Density	1.6±0.1 g/cm3
Boiling Point	494.9±0.0 °C at 760 mmHg
Melting Point	167-170ºC
Molecular Formula	C₆H₁₄O₆
Molecular Weight	182.172
Flash Point	292.5±23.3 °C
Exact Mass	182.079041
PSA	121.38000
LogP	-4.67
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.597

D-Mannitol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OP2060000

CHEMICAL NAME :: Mannitol, D-

CAS REGISTRY NUMBER :: 69-65-8

BEILSTEIN REFERENCE NO. :: 1721898

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H14-O6

MOLECULAR WEIGHT :: 182.20

WISWESSER LINE NOTATION :: Q1YQYQ 2 -BBAA -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 17143 mg/kg/2D-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4308 No. of Facilities: 1555 (estimated) No. of Industries: 14 No. of Occupations: 31 No. of Employees: 41268 (estimated) No. of Female Employees: 28689 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	OP2060000
HS Code	2905430000

Precursor 9
CAS#:57-50-1 sucrose CAS#:3458-28-4 D-Mannose CAS#:9004-34-6 Cellulose micro... CAS#:133-99-3 Cellobiose
CAS#:50-99-7 D-(+)-Glucose CAS#:492-61-5 β-D-Glucopyranose CAS#:57-48-7 Fructose CAS#:470-23-5 D-fructofuranose
CAS#:2280-44-6 D-glucopyranose
DownStream 10
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CAS#:27826-73-9 2,5-Anhydro-D-g... CAS#:41107-82-8 2,5-anhydromannitol

HS Code	2905430000
Summary	HS:2905430000 (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexaol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:8.0% General tariff:30.0%

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China
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China
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China
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D-Mannitol

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