Arecaidine Hydrobromide

Modify Date: 2024-01-13 17:07:38

Arecaidine Hydrobromide Structure
Arecaidine Hydrobromide structure
Common Name Arecaidine Hydrobromide
CAS Number 6013-57-6 Molecular Weight 222.08
Density N/A Boiling Point 266.7ºC at 760 mmHg
Molecular Formula C7H12BrNO2 Melting Point N/A
MSDS N/A Flash Point 115.1ºC

 Use of Arecaidine Hydrobromide


Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

 Names

Name 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrobromide
Synonym More Synonyms

 Arecaidine Hydrobromide Biological Activity

Description Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog
References

[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.  

[2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.  

 Chemical & Physical Properties

Boiling Point 266.7ºC at 760 mmHg
Molecular Formula C7H12BrNO2
Molecular Weight 222.08
Flash Point 115.1ºC
Exact Mass 221.00500
PSA 40.54000
LogP 1.22890

 Synthetic Route

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Arecaidine Hydrobromide Structure

Arecaidine Hydr...

CAS#:6013-57-6

Literature: Freudenberg Chemische Berichte, 1918 , vol. 51, p. 1675

 Synonyms

1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid,hydrobromide
Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide
3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide
1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure,Hydrochlorid
1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure,Hydrobromid
Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide (8CI)
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrobromide
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid hydrobromide
Arecaidine hydrobromide
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