Silymarin

Modify Date: 2024-01-02 18:45:22

Silymarin Structure
Silymarin structure
Common Name Silymarin
CAS Number 65666-07-1 Molecular Weight 482.436
Density 1.5±0.1 g/cm3 Boiling Point 793.0±60.0 °C at 760 mmHg
Molecular Formula C25H22O10 Melting Point N/A
MSDS Chinese USA Flash Point 274.5±26.4 °C

 Use of Silymarin


Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC)[1].

 Names

Name silymarin
Synonym More Synonyms

 Silymarin Biological Activity

Description Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC)[1].
Related Catalog
References

[1]. Féher J, et al. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13(1):210-7.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 793.0±60.0 °C at 760 mmHg
Molecular Formula C25H22O10
Molecular Weight 482.436
Flash Point 274.5±26.4 °C
Exact Mass 482.121307
PSA 155.14000
LogP 2.59
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.684
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VW5503000
CHEMICAL NAME :
Silymarin
CAS REGISTRY NUMBER :
65666-07-1
LAST UPDATED :
199709

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
200 mg/kg
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 61,273,1988

 Safety Information

Safety Phrases S22-S24/25
WGK Germany 3
HS Code 3003909090

 Customs

HS Code 3003909090

 Synonyms

Silymarin + Melatonin
(2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
Silymarin P.E.
MILK THISTLE
EINECS 245-302-5
Silymarin
Silybum marianum
Legalon
silibum marianum extract
4H-1-Benzopyran-4-one, 2-[(2S,3S)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
Legalon 70
MFCD01776359
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