Benzyl-PEG9-THP

Modify Date: 2024-01-10 19:21:58

Benzyl-PEG9-THP Structure
Benzyl-PEG9-THP structure
Common Name Benzyl-PEG9-THP
CAS Number 669556-53-0 Molecular Weight 588.72700
Density N/A Boiling Point N/A
Molecular Formula C30H52O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Benzyl-PEG9-THP


Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-((1-phenyl-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl)oxy)tetrahydro-2H-pyran
Synonym More Synonyms

 Benzyl-PEG9-THP Biological Activity

Description Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C30H52O11
Molecular Weight 588.72700
Exact Mass 588.35100
PSA 101.53000
LogP 2.87920

 Precursor & DownStream

Precursor  0

DownStream  2

 Synonyms

Benzyl-PEG9-THP