Benzyl-PEG5-THP

Modify Date: 2024-01-09 18:40:35

Benzyl-PEG5-THP Structure
Benzyl-PEG5-THP structure
Common Name Benzyl-PEG5-THP
CAS Number 230620-74-3 Molecular Weight 412.517
Density 1.1±0.1 g/cm3 Boiling Point 506.0±50.0 °C at 760 mmHg
Molecular Formula C22H36O7 Melting Point N/A
MSDS N/A Flash Point 197.3±30.0 °C

 Use of Benzyl-PEG5-THP


Benzyl-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[(1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl)oxy]tetrahydro-2H-pyran
Synonym More Synonyms

 Benzyl-PEG5-THP Biological Activity

Description Benzyl-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 506.0±50.0 °C at 760 mmHg
Molecular Formula C22H36O7
Molecular Weight 412.517
Flash Point 197.3±30.0 °C
Exact Mass 412.246094
LogP 0.59
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.502

 Synonyms

MFCD29049394
2-[(1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl)oxy]tetrahydro-2H-pyran
2H-Pyran, tetrahydro-2-[(16-phenyl-3,6,9,12,15-pentaoxahexadec-1-yl)oxy]-
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