THP-PEG9-OH

Modify Date: 2024-01-09 12:59:15

THP-PEG9-OH Structure
THP-PEG9-OH structure
Common Name THP-PEG9-OH
CAS Number 669556-83-6 Molecular Weight 498.60500
Density N/A Boiling Point N/A
Molecular Formula C23H46O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of THP-PEG9-OH


THP-PEG9-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-{2-[2-(2-{2-[2-(2-{2-[2-(Tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol
Synonym More Synonyms

 THP-PEG9-OH Biological Activity

Description THP-PEG9-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C23H46O11
Molecular Weight 498.60500
Exact Mass 498.30400
PSA 112.53000
LogP 0.65470

 Synonyms

THP-PEG9-OH