MK2-IN-3
Modify Date: 2024-04-06 19:10:29
MK2-IN-3 structure
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Common Name | MK2-IN-3 | ||
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| CAS Number | 724711-21-1 | Molecular Weight | 340.37800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H16N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK2-IN-3MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo[1]. |
| Name | 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one |
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| Synonym | More Synonyms |
| Description | MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo[1]. |
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| Related Catalog | |
| Target |
IC50: 8.5 nM (MK-2); 81 nM (MK-5); 210 nM (MK-3); 3.44 μM (ERK2); 5.7 μM (MNK1)[1] |
| In Vitro | MK2-IN-3 (compound 16) inhibits MK-2 and TNFα production in U937 cells, with IC50s of 8.5 nM and 4.4 μM, respectively[1]. |
| In Vivo | MK2-IN-3 (compound 16) (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model[1]. |
| References |
| Molecular Formula | C21H16N4O |
|---|---|
| Molecular Weight | 340.37800 |
| Exact Mass | 340.13200 |
| PSA | 74.16000 |
| LogP | 3.58820 |
| Storage condition | 2-8°C |
| Kinome_3179 |
| 2jbp |
| Pyrrolopyridine,16 |
| 2jbo |
| 3fhr |
| P4O |