SCH 28080

Modify Date: 2024-01-09 19:35:24

SCH 28080 Structure
SCH 28080 structure
Common Name SCH 28080
CAS Number 76081-98-6 Molecular Weight 277.32
Density 1.16g/cm3 Boiling Point N/A
Molecular Formula C17H15N3O Melting Point N/A
MSDS USA Flash Point N/A

 Use of SCH 28080


SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes[1]. Antisecretory and cytoprotective activities[2].

 Names

Name 2-(2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin-3-yl)acetonitrile
Synonym More Synonyms

 SCH 28080 Biological Activity

Description SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes[1]. Antisecretory and cytoprotective activities[2].
Related Catalog
Target

IC50: 20 nM (H+/K+-ATPase, rabbit microsomal membranes)[1]

References

[1]. Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36(1):97-104.

[2]. Long JF, et al. Gastric antisecretory and cytoprotective activities of SCH 28080. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.

 Chemical & Physical Properties

Density 1.16g/cm3
Molecular Formula C17H15N3O
Molecular Weight 277.32
Exact Mass 277.12200
PSA 50.32000
LogP 3.28778
Index of Refraction 1.615
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles29

More Articles
Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K(+) cycling and to active Na(+) extrusion.

Biochim. Biophys. Acta 1830(8) , 4265-73, (2013)

Orthophosphate (Pi) is a central compound in the metabolism of all organisms, including parasites. There are no reports regarding the mechanisms of Pi acquisition by Trypanosoma cruzi.(32)Pi influx wa...

Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.

PLoS ONE 7(12) , e51451, (2012)

Arsenic main inorganic compound is arsenic trioxide (ATO) presented in solution mainly as arsenite. ATO increases intracellular pH (pHi), cell proliferation and tumor growth. Sodium-proton exchangers ...

Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.

Am. J. Physiol. Gastrointest. Liver Physiol. 292(3) , G711-7, (2007)

We have previously shown that stimulation of acid secretion in parietal cells causes rapid initial cell shrinkage, followed by Na(+)/H(+) exchange-mediated regulatory volume increase (RVI). The factor...

 Synonyms

MFCD00834620
Top Suppliers:I want be here




Get all suppliers and price by the below link:

SCH 28080 suppliers


Price: ¥2600/5 mg

Reference only. check more SCH 28080 price