Quinizarin

Modify Date: 2024-01-03 11:16:09

Quinizarin Structure
Quinizarin structure
 Common Name Quinizarin
CAS Number 81-64-1 Molecular Weight 240.211
Density 1.5±0.1 g/cm3 Boiling Point 465.3±40.0 °C at 760 mmHg
Molecular Formula C14H8O4 Melting Point 198-199 °C(lit.)
MSDS Chinese USA Flash Point 249.3±23.8 °C
Symbol GHS09
GHS09		 Signal Word Warning

 Use of Quinizarin


Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2].

 Names

Name quinizarin
Synonym More Synonyms

 Quinizarin Biological Activity

Description Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2].
Related Catalog
In Vitro 1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu(2+) in aqueous solution[1].
References

[1]. Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444(1):50-55.

[2]. Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin.

[3]. Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46(1):367-373.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 465.3±40.0 °C at 760 mmHg
Melting Point 198-199 °C(lit.)
Molecular Formula C14H8O4
Molecular Weight 240.211
Flash Point 249.3±23.8 °C
Exact Mass 240.042252
PSA 74.60000
LogP 4.47
Vapour density 8.3 (vs air)
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.733
Water Solubility <1 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB6600000
CHEMICAL NAME :
Anthraquinone, 1,4-dihydroxy-
CAS REGISTRY NUMBER :
81-64-1
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C14-H8-O4
MOLECULAR WEIGHT :
240.22
WISWESSER LINE NOTATION :
L C666 BV IVJ DQ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82067 No. of Facilities: 563 (estimated) No. of Industries: 10 No. of Occupations: 9 No. of Employees: 6634 (estimated)

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR UN 3077 9 / PGIII
WGK Germany 2
RTECS CB6600000
Packaging Group II; III
Hazard Class 4.1
HS Code 2914610000

 Synthetic Route

 Customs

HS Code 2914610000
Summary 2914610000 anthracene-9,10-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

 Articles35

More Articles
In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.

Antimicrob. Agents Chemother. 51 , 1541-4, (2007)

We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species,...

Synthesis and activity of substituted anthraquinones against a human filarial parasite, Brugia malayi.

J. Med. Chem. 48 , 2822-30, (2005)

Lymphatic filariasis (elephantiasis) is a global public health problem caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. We have previously reported anthraquinones from daylily...

Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy.

Eur. J. Med. Chem. 45 , 1001-7, (2010)

Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals form...

 Synonyms

MFCD00001209
EINECS 201-368-7
1,4-hydroxyanthraquinone
QUINIZARINE
DSD ACID
smokeoranger
1,4-Dihydroxy-9,10-anthraquinone
Quinizarin
Chinizarin
1,4-Dihydroxy-9,10-anthracene-dione
1,4-Dihydroxyanthraquinone
9,10-Anthracenedione, 1,4-dihydroxy-
Quinizalin
QUINAZARIN
1,4-Doa
1,4-dihydroxyanthracene-9,10-dione
quiniazarine
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Related Compounds: More...
Quinizarin
103220-12-8
QUINIZARIN
137612-86-3
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476-60-8
quinizarin green
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2-sulfoquinizarine
145-48-2
Quinizarin Green SS
128-80-3
Quinizarin,2-chloro
81-53-8
quinizarin diacetate
2289-36-3
quinizarin ditosylate
96701-06-3
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205067-45-4
Chemsrc provides Quinizarin(CAS#:81-64-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Quinizarin are included as well.>> amp version: Quinizarin

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