PSB 0474

Modify Date: 2024-01-12 16:46:58

PSB 0474 Structure
PSB 0474 structure
Common Name PSB 0474
CAS Number 917567-60-3 Molecular Weight 522.29
Density N/A Boiling Point N/A
Molecular Formula C17H20N2O13P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PSB 0474


PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].

 Names

Name PSB 0474,3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphatedisodiumsalt
Synonym More Synonyms

 PSB 0474 Biological Activity

Description PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].
Related Catalog
Target

IC50: 70 nM (P2Y6)[1]

References

[1]. Ali El-Tayeb, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87.

[2]. Clara Quintas, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014 Sep 3;11:141.

 Chemical & Physical Properties

Molecular Formula C17H20N2O13P2
Molecular Weight 522.29
Exact Mass 566.00800
PSA 249.33000

 Synonyms

3-phenacyl udp disodium salt
psb 0474