ONO-RS-082
ONO-RS-082 structure
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Common Name | ONO-RS-082 | ||
|---|---|---|---|---|
| CAS Number | 99754-06-0 | Molecular Weight | 371.85700 | |
| Density | 1.247g/cm3 | Boiling Point | 580.5ºC at 760mmHg | |
| Molecular Formula | C21H22ClNO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 304.9ºC | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of ONO-RS-082ONO-RS-082 is an inhibitor of phospholipase A (PLA)[1]. ONO-RS-082 inhibits PLA2 with the IC50 of 1.0 μM, but does not inhibit PLC even at 100 μM[2]. |
| Name | 4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | ONO-RS-082 is an inhibitor of phospholipase A (PLA)[1]. ONO-RS-082 inhibits PLA2 with the IC50 of 1.0 μM, but does not inhibit PLC even at 100 μM[2]. |
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| Related Catalog | |
| In Vitro | ONO-RS-082 (10 μM) prevents P. aeruginosa strain PAO1-induced polymorphonumclear cells (PMNs) transepithelial migration, demonstrating that PLA2 activity is crucial to this process[3]. Cell Viability Assay[3] Cell Line: A549 lung epithelial cell lines Concentration: 10 μM Incubation Time: 2-h pretreatment Result: Completely blocked HXA3-mediated PAO1-induced PMN transepithelial migration. Largely prevented PAO1-induced PGE2 release. |
| In Vivo | In vivo long-term activation of KCNK3 by ONO-RS-082 (50 mg/kg/day; preventive treatment, day 0 to day 21) reduces the development of PH in the MCT-PH model[4]. In contrast, in vivo short-term KCNK3 activation by ONO-RS-082 (curative treatment) fails to reduce PH symptoms, which is attributed to the complete loss of KCNK3 expression in MCT-PH rats at days 14 to 21[4]. Animal Model: MCT- pulmonary hypertension (PH) rat model[4] Dosage: 50 mg/kg/day Administration: Result: Reduced the development of PH in the MCT-PH model for long-term. |
| References |
| Density | 1.247g/cm3 |
|---|---|
| Boiling Point | 580.5ºC at 760mmHg |
| Molecular Formula | C21H22ClNO3 |
| Molecular Weight | 371.85700 |
| Flash Point | 304.9ºC |
| Exact Mass | 371.12900 |
| PSA | 66.40000 |
| LogP | 5.49580 |
| Index of Refraction | 1.633 |
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Role of phospholipase A(2) in retrograde transport of ricin.
Toxins (Basel.) 3(9) , 1203-19, (2011) Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a ... |
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A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking.
Traffic 11(12) , 1530-6, (2010) We have investigated the role of phospholipase A(2) (PLA(2) ) enzymes in generating membrane tubules at the trans-Golgi network (TGN). Constitutive TGN membrane tubules and those induced by over-expre... |
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Pyrimidine nucleotide-stimulated thromboxane A2 release from cultured glia.
Cell. Mol. Neurobiol. 18(5) , 477-86, (1998) 1. Uridine triphosphate (UTP), uridine diphosphate (UDP), cytidine triphosphate (CTP), and deoxythymidine triphosphate (TTP) caused concentration-dependent increases in the release of thromboxane A2 (... |
| Ono-RS-082 |
| C21H22ClNO3 |