KRAS inhibitor-13

Modify Date: 2024-01-11 16:22:58

KRAS inhibitor-13 structure	Common Name	KRAS inhibitor-13
	CAS Number	2230873-96-6	Molecular Weight	479.95
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₁₉ClFN₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KRAS inhibitor-13

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

Name	KRAS inhibitor-13

Description	KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12C:0.883 μM (IC50)
References	[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Molecular Formula	C₂₅H₁₉ClFN₃O₂S
Molecular Weight	479.95

KRAS inhibitor-13

Use of KRAS inhibitor-13

Names

KRAS inhibitor-13 Biological Activity

Chemical & Physical Properties