![]() NF-κB-IN-5 structure
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Common Name | NF-κB-IN-5 | ||
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CAS Number | 2425675-52-9 | Molecular Weight | 409.48 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C23H27N3O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of NF-κB-IN-5NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1]. |
Name | NF-κB-IN-5 |
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Description | NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1]. |
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Related Catalog | |
In Vivo | NF-κB-IN-5 (C57BL/6 mice bearing MC38, 40.0 mg/kg, PO, for 12 days, once a day) shows promising antitumor activity against mice colon tumor[1]. |
References |
Molecular Formula | C23H27N3O4 |
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Molecular Weight | 409.48 |