P2X7 receptor antagonist-2

Modify Date: 2024-01-29 17:32:49

P2X7 receptor antagonist-2 Structure
P2X7 receptor antagonist-2 structure
Common Name P2X7 receptor antagonist-2
CAS Number 851269-75-5 Molecular Weight 377.264
Density 1.4±0.1 g/cm3 Boiling Point 640.1±55.0 °C at 760 mmHg
Molecular Formula C19H18Cl2N2O2 Melting Point N/A
MSDS N/A Flash Point 340.9±31.5 °C

 Use of P2X7 receptor antagonist-2


P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC50 value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation[1].

 Names

Name 1-Benzyl-N-(2,4-dichlorobenzyl)-5-oxo-3-pyrrolidinecarboxamide
Synonym More Synonyms

 P2X7 receptor antagonist-2 Biological Activity

Description P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC50 value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation[1].
Related Catalog
Target

pIC50:6.5-7.5 (P2X7 receptor)[1]

References

[1]. Steadman JGA, et, al. 5-oxo-3-pyrrolidinecarboxamide derivatives as p2x7 modulators. WO2009077559A2

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 640.1±55.0 °C at 760 mmHg
Molecular Formula C19H18Cl2N2O2
Molecular Weight 377.264
Flash Point 340.9±31.5 °C
Exact Mass 376.074524
LogP 2.87
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.622

 Synonyms

1-Benzyl-N-(2,4-dichlorobenzyl)-5-oxo-3-pyrrolidinecarboxamide
3-Pyrrolidinecarboxamide, N-[(2,4-dichlorophenyl)methyl]-5-oxo-1-(phenylmethyl)-