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那可丁

那可丁用途

Noscapine是一种口服止咳药, 主要通过其 σ受体激动剂活性调节, 且Noscapine具有抗癌活性。

那可丁名称

[ CAS 号 ]:
128-62-1

[ 中文名 ]:
那可汀

[ 英文名 ]:
Noscapine

[中文别名 ]:

[英文别名 ]:

MFCD00069316
Coscopin
Noscapal
Vadebex
Vadebe
[3H]-Noscapine
l-α-Narcotine
Narcosine
Narcotussin
Key-tusscapine

那可丁生物活性

[ 描述 ]:

Noscapine是一种口服止咳药, 主要通过其 σ受体激动剂活性调节, 且Noscapine具有抗癌活性。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Sigma Receptor

研究领域 >> 癌症

[参考文献]

[1]. Yang Y, et al. CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism. Theranostics. 2015 Mar 2;5(7):656-666.

[相关活性小分子]

UNC0642 | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 | BD-1047 | PRE-084 | BD1063 | 西拉美新盐酸盐 | Roluperidone | 4-IBP | AVex-73 hydrochloride | S1RA盐酸盐 | 磷酸二甲啡烷 | σ-配体-1

那可丁物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
565.3±50.0 °C at 760 mmHg

[ 熔点 ]:
174-176ºC

[ 分子式 ]:
C₂₂H₂₃NO₇

[ 分子量 ]:
413.421

[ 闪点 ]:
295.7±30.1 °C

[ 精确质量 ]:
413.147461

[ PSA ]:
75.69000

[ LogP ]:
2.83

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.603

[ 储存条件 ]:
-20℃

那可丁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD2625000

CHEMICAL NAME :: Noscapine

CAS REGISTRY NUMBER :: 128-62-1

BEILSTEIN REFERENCE NO. :: 0099933

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C22-H23-N-O7

MOLECULAR WEIGHT :: 413.46

WISWESSER LINE NOTATION :: T C566 DO FO KN EH&&TJ HO1 K1 J- DT56 BVO DHJ HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 853 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 725 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 73200 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 100 mg/L

REFERENCE :: ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 4,41,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84631 No. of Facilities: 1254 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2211 (estimated)

那可丁安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
UN 1544

[ WGK德国 ]:
3

[ RTECS号 ]:
RD2625000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

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那可丁文献

Determinants of increased opioid-related mortality in the United States and Canada, 1990-2013: a systematic review.

Am. J. Public Health 104(8) , e32-42, (2014)

We review evidence of determinants contributing to increased opioid-related mortality in the United States and Canada between 1990 and 2013. We identified 17 determinants of opioid-related mortality a...

Adlumiceine methyl ester, a new alkaloid from Fumaria vaillantii.

J. Asian Nat. Prod. Res. 16(12) , 1148-52, (2014)

A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The struct...

Peloruside, laulimalide, and noscapine interactions with beta-tubulin.

Pharm. Res. 29(11) , 2985-93, (2012)

This article reviews the recent findings regarding the binding sites, binding modes and binding affinities of three novel antimitotic drugs peloruside, laulimalide and noscapine with respect to tubuli...

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