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丁酸钠

丁酸钠用途

Sodium Butyrate是一种短链脂肪酸,可以抑制组蛋白去乙酰化酶。

丁酸钠作用

减少细胞内Ca2+ 的释放。抑制组蛋白脱乙酰酶(HDAC)，诱导细胞凋亡。

丁酸钠名称

[ CAS 号 ]:
156-54-7

[ 中文名 ]:
丁酸钠

[ 英文名 ]:
Sodium butyrate

[中文别名 ]:

[英文别名 ]:

MFCD00002816
Butyrate sodium salt
Natriumbutyrat
Na butyrate
EINECS 205-857-6
SODIUM BUTYRATE pure
NAB
BUTYRIC ACID NA
Sodium butanoate
SODIUM N-BUTYLATE

丁酸钠生物活性

[ 描述 ]:

Sodium Butyrate是一种短链脂肪酸,可以抑制组蛋白去乙酰化酶。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 细胞周期/DNA损伤 >> HDAC

信号通路 >> 表观遗传学 >> HDAC

研究领域 >> 癌症

[ 靶点 ]

HDAC

[体外研究]

丁酸钠诱导形态学变化,抑制细胞增殖并损害NPC细胞的细胞活力。丁酸钠(1,5,10mM)对NPC细胞具有细胞毒性,在5-8F和6-10B细胞中诱导细胞活力的剂量和时间依赖性降低。丁酸钠通过激活线粒体凋亡轴诱导鼻咽癌细胞凋亡。此外,SOCE抑制和破坏CRAC通道可以减弱丁酸钠诱导的细胞凋亡[1]。丁酸钠显着降低细胞活力,同时降低p-mTOR和PCNA蛋白的水平。丁酸钠以剂量依赖性方式诱导细胞周期停滞在G0/G1期并减少S期细胞数量。此外,较高浓度的丁酸钠(1,5,10mM)增加p21,p27和促凋亡bak基因的相对表达,以及p21Waf1/Cip1,p27Kip1,cyclinD3,CDK4和Cleave-caspase3的蛋白水平。 ),cyclinD1和CDK6的水平降低5和10mM丁酸盐[3]。

[体内研究]

HI后立即给予丁酸钠(300mg/kg,sc),与未处理的动物相比,提供了几乎完全的神经保护作用。丁酸钠给药导致小侧神经细胞数量增加至同侧的载体治疗动物的150％。在新生儿缺氧缺血后,丁酸钠促进小胶质细胞从M1-到M2样表型的极化[2]。丁酸钠(300 mg/kg,sc)与AK-7(20 mg/kg,ip)联合使用可显着减轻探索新物体所花费的时间,减少Ki67阳性细胞和DCX-的数量减少小鼠齿状回中的免疫反应性成神经细胞。此外,丁酸钠可逆转SIRT2相关的年龄表型[4]。

[细胞实验]

将细胞以2,000个细胞/孔的密度接种在96孔板中，其中200μL培养基含有不同浓度的丁酸钠。然后，将细胞连续培养72小时。每24小时，将20μL5mg/ mL MTT溶液加入相应的孔中，并将细胞再培养4小时。然后，用150μL二甲基亚砜代替溶液，然后在室温下温和搅拌板15分钟。最后，测量492nm处的吸光度以代表细胞活力。

[动物实验]

对7日龄大鼠幼鼠进行单侧颈动脉结扎，然后进行60分钟的缺氧（7.6％O2）。丁酸钠（300mg / kg）以5天的方式给药，在缺氧暴露后立即给予第一次注射。在损伤后6天通过苏木精 - 伊红染色评估同侧半球的损伤。在24和48小时和6天收集样品。

[参考文献]

[1]. Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929

[2]. Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34

[3]. Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27

[4]. Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230

[5]. Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.

[相关活性小分子]

丁酸钠物理化学性质

[ 密度 ]:
0.987g/cm3

[ 沸点 ]:
164.3ºC at 760 mmHg

[ 熔点 ]:
250-253 °C(lit.)

[ 分子式 ]:
C₄H₇NaO₂

[ 分子量 ]:
110.087

[ 闪点 ]:
69.7ºC

[ 精确质量 ]:
110.034370

[ PSA ]:
40.13000

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
1.35mmHg at 25°C

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stable. Incompatible with strong acids.

[ 水溶解性 ]:
soluble

丁酸钠MSDS

详细MSDS(安全技术说明书)

丁酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET6400000

CHEMICAL NAME :: Butyric acid, sodium salt

CAS REGISTRY NUMBER :: 156-54-7

LAST UPDATED :: 199803

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C4-H8-O2.Na

MOLECULAR WEIGHT :: 111.11

WISWESSER LINE NOTATION :: OV3 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Mammal - cattle Lymphocyte

DOSE/DURATION :: 4 mmol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 51,141,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82158 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 184 (estimated) No. of Female Employees: 101 (estimated)

丁酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26-S24/25

[ 危险品运输编码 ]:
2820

[ WGK德国 ]:
1

[ RTECS号 ]:
ET6400000

[ 海关编码 ]:
2915600000

丁酸钠合成路线

详细合成路线

丁酸钠上下游产品

丁酸钠上游产品

丁酸钠下游产品

丁酸钠海关

[ 海关编码 ]: 2915600000

[ 中文概述 ]:
HS:2915600000 丁酸、戊酸及其盐和酯增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2915600000 butanoic acids and pentanoic acids and their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

丁酸钠文献

Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

PLoS Biol. 12(1) , e1001758, (2014)

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of ep...

Short-chain fatty acids and acidic pH upregulate UT-B, GPR41, and GPR4 in rumen epithelial cells of goats.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(4) , R283-93, (2015)

Currently, the mechanism(s) responsible for the regulation of urea transporter B (UT-B) expression levels in the epithelium of the rumen remain unclear. We hypothesized that rumen fermentation product...

The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.

J. Mol. Biol. 426(24) , 3960-72, (2014)

In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional r...

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丁酸钠