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野黄芩素

野黄芩素用途

野黄芩素(Scutellarein) 是天然黄酮类化合物,具有抗炎功效。

野黄芩素名称

[ CAS 号 ]:
529-53-3

[ 中文名 ]:
野黄芩素

[ 英文名 ]:
Scutellarein

[中文别名 ]:

[英文别名 ]:

5,6,7,4'-tetrahydroxyflavone
4',5,6,7-Tetrahydroxyflavanone
6-Hydroxypelargidenon 1465
Scutellarein

野黄芩素生物活性

[ 描述 ]:

野黄芩素(Scutellarein) 是天然黄酮类化合物,具有抗炎功效。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 蛋白酪氨酸激酶 >> SRC

研究领域 >> 炎症/免疫

天然产物 >> 黄酮类化合物

[参考文献]

[1]. Xiaoxuan Tian, et al. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. Biological and Pharmaceutical BulletinVol. 39 (2016) No. 2 p. 181-191

[2]. Sung NY, et al. Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity. Korean J Physiol Pharmacol. 2015 Sep;19(5):441-9.

[相关活性小分子]

野黄芩素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
642.9±55.0 °C at 760 mmHg

[ 熔点 ]:
330ºC

[ 分子式 ]:
C₁₅H₁₀O₆

[ 分子量 ]:
286.236

[ 闪点 ]:
249.9±25.0 °C

[ 精确质量 ]:
286.047729

[ PSA ]:
111.13000

[ LogP ]:
2.54

[ 外观性状 ]:
yellow

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.768

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: soluble1mg/mL, clear, greenish-yellow

野黄芩素MSDS

野黄芩素安全信息

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2914501900

野黄芩素合成路线

野黄芩素上下游产品

野黄芩素上游产品

野黄芩素下游产品

野黄芩素海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

野黄芩素文献

Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.

Biol. Pharm. Bull. 39 , 181-91, (2016)

Erigeron breviscapus has been widely used in traditional Chinese medicine (TCM) and its total flavonoid component is commonly used to treat ischemic stroke, coronary heart disease, diabetes and hypert...

Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).

J. Chromatogr. Sci. 53 , 1140-6, (2015)

A novel free radical reaction combined with high-performance LC-photodiode array-ESI-MS/MS screening method was developed for the detection and identification of natural antioxidants from whole Scutel...

Effect of light, methyl jasmonate and cyclodextrin on production of polyphenolic compounds in hairy root cultures of Scutellaria lateriflora

Phytochemistry 107 , 50-60, (2014)

Graphical abstract [Display omitted]

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