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1,2-戊二醇

1,2-戊二醇用途

【用途一】
1，2-戊二醇是杀菌剂丙环唑的重要中间体。

1,2-戊二醇名称

[ CAS 号 ]:
5343-92-0

[ 中文名 ]:
1,2-戊二醇

[ 英文名 ]:
1,2-Pentanediol

[中文别名 ]:

[英文别名 ]:

PENTANDIOL-1,2
PTD
Pentane-1,2-diol
propylethylene glycol
1,2-Pentanediol
1,2,pentandiol
Pentanediol
EINECS 226-285-3
n-pentane-1,2-diol
pentylene glycol

1,2-戊二醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
206.0±0.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₁₂O₂

[ 分子量 ]:
104.148

[ 闪点 ]:
104.4±0.0 °C

[ 精确质量 ]:
104.083733

[ PSA ]:
40.46000

[ LogP ]:
-0.28

[ 外观性状 ]:
纯无色至淡黄色液体

[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C

[ 折射率 ]:
1.443

[ 储存条件 ]:
室温

[ 水溶解性 ]:
miscible

1,2-戊二醇MSDS

详细MSDS(安全技术说明书)

1,2-戊二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SA0455000

CHEMICAL NAME :: 1,2-Pentanediol

CAS REGISTRY NUMBER :: 5343-92-0

BEILSTEIN REFERENCE NO. :: 1719151

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H12-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(9),14,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(9),14,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(9),14,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(9),14,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/kg/28W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(9),14,1973

1,2-戊二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
SA0455000

[ 海关编码 ]:
2905399090

1,2-戊二醇上下游产品

1,2-戊二醇上游产品

1,2-戊二醇下游产品

1,2-戊二醇制备

其制备方法是用1-戊烯、过氧化氢和甲酸为原料，其摩尔比为1∶1.5∶4。该反应平衡混合物是通过下列程序形成的：慢慢地将1-戊烯和过氧化氢(70％)同时在40～55℃加入到甲酸中，加完后，将混合物在55℃搅拌1h，移入循环反应釜，该反应釜具有循环泵和溢流虹吸管，加热到55℃并进行循环，然后加入1-戊烯和甲酸，由一个加入管加入，过氧化氢从另一加入管加入，此时发生放热反应，温度容许升到62～63℃，按照一定的比例和速度加入这些组分，平衡操作以循环恒温装置控制，进行约8h，反应停止，得到大量1，2-戊二醇的甲酸酯，减压蒸馏除去甲酸和水，得到的残余物加入25％NaOH溶液进行水解，溶剂萃取脱溶蒸馏而得到1，2-戊二醇，收率可达91％，m p.96～98℃/1.3kPa。

1,2-戊二醇海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

1,2-戊二醇文献

The use of water-soluble mucoadhesive gels for the intravesical delivery of epirubicin to the bladder for the treatment of non-muscle-invasive bladder cancer.

J. Pharm. Pharmacol. 67 , 1355-62, (2015)

To develop an epirubicin-loaded, water-soluble mucoadhesive gels that have the correct rheological properties to facilitate their delivery into the bladder via a catheter, while allowing for their spr...

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