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异丁香酚甲醚

异丁香酚甲醚用途

甲基异丁烯醇(MIE)是一种天然的食用香料,可以从假石竹叶中分离出来。甲基异丁烯醇具有抗焦虑和抗抑郁样作用。甲基异丁烯醇具有口服活性[1]。

异丁香酚甲醚名称

[ CAS 号 ]:
93-16-3

[ 中文名 ]:
异丁香酚甲醚

[ 英文名 ]:
(E)-methyl isoeugenol

[中文别名 ]:

[英文别名 ]:

4-Propenylveratrole
1,3,4-Isoeugenol methyl ether
trans-Methylisoeugenol
isomethyleugenol
4-trans-Propenylveratrole
benzene, 1,2-dimethoxy-4-(1-propen-1-yl)-
1,2-Dimethoxy-4-((E)-propenyl)-benzene
1-Propene, 1-(3,4-dimethoxyphenyl)-
Isoeugenyl methyl ether
trans-Methyl isoeugenol

异丁香酚甲醚生物活性

[ 描述 ]:

甲基异丁烯醇(MIE)是一种天然的食用香料,可以从假石竹叶中分离出来。甲基异丁烯醇具有抗焦虑和抗抑郁样作用。甲基异丁烯醇具有口服活性[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Fajemiroye JO, et al. Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol. Food Funct. 2014 Aug;5(8):1819-28.

异丁香酚甲醚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
271.1±20.0 °C at 760 mmHg

[ 熔点 ]:
98-100 °C(lit.)

[ 分子式 ]:
C₁₁H₁₄O₂

[ 分子量 ]:
178.23

[ 闪点 ]:
104.5±21.3 °C

[ 精确质量 ]:
178.099380

[ PSA ]:
18.46000

[ LogP ]:
3.05

[ 外观性状 ]:
液体;Colorless to Light yellow clear liquid

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
2~8°C

异丁香酚甲醚MSDS

异丁香酚甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ7000000

CHEMICAL NAME :: Benzene, 1,2-dimethoxy-4-propenyl-

CAS REGISTRY NUMBER :: 93-16-3

BEILSTEIN REFERENCE NO. :: 0880472

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C11-H14-O2

MOLECULAR WEIGHT :: 178.25

WISWESSER LINE NOTATION :: 2U1R CO1 DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,865,1975 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,865,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 199,226,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 199,226,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,865,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in leukocyte (WBC) count

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,475,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83230 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 207 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83230 No. of Facilities: 1391 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 15097 (estimated) No. of Female Employees: 10177 (estimated)

异丁香酚甲醚安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
CZ7000000

[ 海关编码 ]:
2909309090

异丁香酚甲醚合成路线

异丁香酚甲醚上下游产品

异丁香酚甲醚上游产品

异丁香酚甲醚下游产品

异丁香酚甲醚制备

由异丁香酚精甲基化而制得。

异丁香酚甲醚海关

[ 海关编码 ]: 2909309090

[ 中文概述 ]:
2909309090 其他芳香醚及其卤化衍生物、磺化、硝化衍生物（包括亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

异丁香酚甲醚文献

Neural coding of binary mixtures in a structurally related odorant pair.

Sci. Rep. 3 , 1220, (2013)

The encoding of odorant mixtures by olfactory sensory neurons depends on molecular interactions at peripheral receptors. However, the pharmacological basis of these interactions is not well defined. B...

Chemical composition of the essential oil of Feronia elephantum Correa.

Nat. Prod. Res. 24(19) , 1807-10, (2010)

The essential oil composition of Feronia elephantum Correa (family: Rutaceae) was examined by capillary gas chromatography (GC) and gas chromatography-mass spectroscopy (GC-MS). The analysis revealed ...

A call for full ingredient labelling and uniform nomenclature on medicaments.

Br. J. Dermatol. 161(2) , 489-90, (2009)

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