CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
YR0350000
-
CHEMICAL NAME :
-
Uracil, 5-fluoro-
-
CAS REGISTRY NUMBER :
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51-21-8
-
LAST UPDATED :
-
199710
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DATA ITEMS CITED :
-
156
-
MOLECULAR FORMULA :
-
C4-H3-F-N2-O2
-
MOLECULAR WEIGHT :
-
130.09
-
WISWESSER LINE NOTATION :
-
T6MVMVJ EF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Human
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
450 mg/kg/30D
-
TOXIC EFFECTS :
-
Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Tumorigenic - active as anti-cancer agent
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
6 mg/kg/3D
-
TOXIC EFFECTS :
-
Cardiac - EKG changes not diagnostic of specified effects Cardiac - other changes Lungs, Thorax, or Respiration - other changes
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
150 mg/kg/17W-I
-
TOXIC EFFECTS :
-
Blood - other hemolysis with or without anemia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
39 mg/kg/1D-I
-
TOXIC EFFECTS :
-
Cardiac - changes in coronary arteries
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Human - woman
-
DOSE/DURATION :
-
27 mg/kg/4D-C
-
TOXIC EFFECTS :
-
Cardiac - other changes
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
230 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
70 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
217 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
245 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
240 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Parenteral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
500 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Rectal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
884 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
115 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
100 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
169 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
81 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intracerebral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
41600 ug/kg
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Sense Organs and Special Senses (Eye) - ptosis Sense Organs and Special Senses (Eye) - effect, not otherwise specified
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intratracheal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
200 mg/kg
-
TOXIC EFFECTS :
-
Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
171 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
30 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - nausea or vomiting
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
18900 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
15 mg/kg
-
TOXIC EFFECTS :
-
Vascular - BP elevation not characterized in autonomic section
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
25 mg/kg
-
TOXIC EFFECTS :
-
Vascular - BP elevation not characterized in autonomic section
-
TYPE OF TEST :
-
LD10 - Lethal Dose
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ROUTE OF EXPOSURE :
-
Parenteral
-
SPECIES OBSERVED :
-
Rodent - hamster
-
DOSE/DURATION :
-
140 mg/kg
-
TOXIC EFFECTS :
-
Tumorigenic - active as anti-cancer agent
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
2520 mg/kg/12W-I
-
TOXIC EFFECTS :
-
Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - changes in testicular weight
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1092 mg/kg/30D-I
-
TOXIC EFFECTS :
-
Endocrine - changes in thymus weight Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
6552 mg/kg/26W-I
-
TOXIC EFFECTS :
-
Endocrine - changes in thymus weight Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
700 mg/kg/40W-I
-
TOXIC EFFECTS :
-
Nutritional and Gross Metabolic - weight loss or decreased weight gain Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1283 mg/kg/13W-C
-
TOXIC EFFECTS :
-
Behavioral - fluid intake Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
360 mg/kg/60D-I
-
TOXIC EFFECTS :
-
Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
780 mg/kg/30D-I
-
TOXIC EFFECTS :
-
Endocrine - changes in thymus weight Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
2340 mg/kg/13W-I
-
TOXIC EFFECTS :
-
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - normocytic anemia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
21 mg/kg/7D-I
-
TOXIC EFFECTS :
-
Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Blood - changes in platelet count
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Rectal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
4920 mg/kg/90D-I
-
TOXIC EFFECTS :
-
Gastrointestinal - other changes Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Rectal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
9540 mg/kg/26W-I
-
TOXIC EFFECTS :
-
Gastrointestinal - other changes Endocrine - other changes Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
300 mg/kg/60D-I
-
TOXIC EFFECTS :
-
Endocrine - changes in spleen weight Related to Chronic Data - death Related to Chronic Data - changes in testicular weight
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
455 mg/kg/13W-I
-
TOXIC EFFECTS :
-
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
175 mg/kg/5W-I
-
TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
1500 mg/kg/50W-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
DOSE :
-
150 mg/kg
-
SEX/DURATION :
-
female 20-31 week(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - other neonatal measures or effects
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
DOSE :
-
240 mg/kg
-
SEX/DURATION :
-
female 11-14 week(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
35 mg/kg
-
SEX/DURATION :
-
female 7-13 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
175 mg/kg
-
SEX/DURATION :
-
female 7-13 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
15 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
30 mg/kg
-
SEX/DURATION :
-
female 12 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - gastrointestinal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
30 mg/kg
-
SEX/DURATION :
-
female 12 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - homeostasis
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
20 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
20 mg/kg
-
SEX/DURATION :
-
female 14 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
DOSE :
-
30 mg/kg
-
SEX/DURATION :
-
female 14 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
DOSE :
-
330 mg/kg
-
SEX/DURATION :
-
female 7-17 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
175 mg/kg
-
SEX/DURATION :
-
female 7-13 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
245 mg/kg
-
SEX/DURATION :
-
female 7-13 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
50 mg/kg
-
SEX/DURATION :
-
female 13 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
20 mg/kg
-
SEX/DURATION :
-
female 10 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
20 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
30 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - abortion
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
10 mg/kg
-
SEX/DURATION :
-
female 10 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
30 mg/kg
-
SEX/DURATION :
-
female 12 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
DOSE :
-
67 mg/kg
-
SEX/DURATION :
-
male 1 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
24 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
28 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
56 mg/kg
-
SEX/DURATION :
-
female 11 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - homeostasis
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
20 mg/kg
-
SEX/DURATION :
-
female 9 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
-
TYPE OF TEST :
-
Specific locus test
-
TYPE OF TEST :
-
DNA inhibition
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
DNA inhibition
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TYPE OF TEST :
-
Sperm Morphology
-
TYPE OF TEST :
-
Sperm Morphology
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Cytogenetic analysis
MUTATION DATA
-
TYPE OF TEST :
-
DNA inhibition
-
TEST SYSTEM :
-
Mammal - species unspecified Cells - not otherwise specified
-
DOSE/DURATION :
-
100 umol/L
-
REFERENCE :
-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 120,139,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,217,1981 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,217,1981 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,210,1987 TOXICOLOGY REVIEW NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 291,75,1974 TOXICOLOGY REVIEW MIMDAL Minnesota Medicine. (Minnesota Medical Assoc., 2221 University Ave., SE, Suite 400, Minneapolis, MN 55414) V.1- 1918- Volume(issue)/page/year: 57,19,1974 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 172,1765,1960 TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 144,429,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4035 No. of Facilities: 681 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 23501 (estimated) No. of Female Employees: 15547 (estimated)
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