90-89-1

• 常用中文名：乙胺嗪
• 常用英文名：Diethylcarbamazine
• CAS号：90-89-1
• 分子式：C₁₀H₂₁N₃O
• 分子量：199.29300
• 相关类别： 原料药 抗寄生虫病药 抗丝虫病及抗利什曼原虫病药
• 发布时间：2018-08-21 19:15:38
• 更新时间：2024-01-12 12:30:58
• 二乙基氨基甲嗪是一种杀微丝药物,最初用于盘尾丝虫病和淋巴丝虫病研究[1]。

名称

• 中文名: 乙胺嗪
• 英文名: n,n-diethyl-4-methyl-1-piperazinecarboxamide
• 中文别名: 1-二乙胺基甲酰基-4-甲基哌嗪; 海群众
• 英文别名: patonin; 4-methyl-piperazine-1-carboxylic acid diethylamide; Caracide; 84L; Caricide; Notezine; rp3799; Cypip; diethycarbamazine; Banocide; 4-Methyl-piperazin-1-carbonsaeure-diaethylamid; Diethylcarbamazine; Ethodryl

物化性质

• 密度: 1.013g/cm3
• 沸点: 139ºC
• 熔点: 137 - 140ºC
• 分子式: C₁₀H₂₁N₃O
• 分子量: 199.29300
• 闪点: 98ºC
• 精确质量: 199.16800
• PSA: 26.79000
• LogP: 0.57140
• 外观性状: 灰白色结晶粉末
• 折射率: 1.492
• 储存条件: 存放于惰性气体之中;避免空气

生物活性

• 描述: 二乙基氨基甲嗪是一种杀微丝药物,最初用于盘尾丝虫病和淋巴丝虫病研究[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. M García-Hernández, et al. Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis. Int Immunopharmacol. 2014 Nov;23(1):113-20.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TL1200000 CHEMICAL NAME : 1-Piperazinecarboxamide, N,N-diethyl-4-methyl- CAS REGISTRY NUMBER : 90-89-1 BEILSTEIN REFERENCE NO. : 0143029 LAST UPDATED : 199701 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C10-H21-N3-O MOLECULAR WEIGHT : 199.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 7300 mg/kg/1Y-I TOXIC EFFECTS : Skin and Appendages - dermatitis, allergic (after systemic exposure) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 630 mg/kg SEX/DURATION : female 7-11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : Micronucleus test MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 40 mg/kg REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 44,7,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2728 No. of Facilities: 316 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 3161 (estimated) No. of Female Employees: 1581 (estimated)

合成路线

88-10-8 ~% 90-89-1

文献：Journal of Organic Chemistry, , vol. 13, p. 144,149

109-01-3 88-10-8 ~% 90-89-1

文献：Journal of Organic Chemistry, , vol. 13, p. 144,149

50-00-0 119-54-0 ~% 90-89-1

文献：Journal of Organic Chemistry, , vol. 13, p. 144,149

109-01-3 ~% 90-89-1

文献：Bulletin des Societes Chimiques Belges, , vol. 58, p. 103,104

39539-66-7 109-89-7 ~% 90-89-1

文献：Bulletin des Societes Chimiques Belges, , vol. 58, p. 103,104 Yakugaku Zasshi, , vol. 76, p. 605 Chem.Abstr., , p. 434

51-75-2 ~% 90-89-1

文献：Chemicke Zvesti, , vol. 6, p. 353

109-01-3 65009-00-9 ~% 90-89-1

文献：DE923967 , ;