58551-69-2

• 常用中文名：卡前列素氨基丁三醇
• 常用英文名：Carboprost tromethamine
• CAS号：58551-69-2
• 分子式：C₂₅H₄₇NO₈
• 分子量：489.643
• 相关类别： 原料药 激素及调节内分泌功能类药 前列腺素类药
• 发布时间：2018-04-04 08:00:00
• 更新时间：2024-01-01 17:58:59
• Carboprost tromethamine 是前列腺素 F2α (prostaglandin F2α) 的 15 甲基类似物。Carboprost tromethamine 能有效促进子宫规律性收缩,显著减少产后出血量。

名称

• 中文名: 卡前列素氨基丁三醇
• 英文名: carboprost tromethamine
• 中文别名: (Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇; 卡前列腺氨丁三醇
• 英文别名: (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(3S)-3-hydroxy-3-methyl-1-octenyl)cyclopentyl)-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1); (15S)-15-Methylprostaglandin F2a Tromethamine; (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); (5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl}hept-5-ensäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1); Hemabate; Prostin/15M; acide (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-méthyloct-1-én-1-yl]cyclopentyl}hept-5-énoïque - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1); Carboprost tromethamine salt; 15(S)15-Methyl pgf2a Tromethamine Salt; Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9α,11α,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); (5Z,9a,11a,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-dien-1-oic Acid compd. with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1); Carboprost trometamol; Carboprost tromethamine; U 32921E; (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl}hept-5-enoic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

物化性质

• 密度: 1.153g/cm3
• 沸点: 536.6ºC at 760 mmHg
• 分子式: C₂₅H₄₇NO₈
• 分子量: 489.643
• 闪点: 292.4ºC
• 精确质量: 489.330170
• PSA: 184.70000
• LogP: 1.79410
• 储存条件: 2-8°C，密闭，干燥
• 水溶解性: Soluble in water.

生物活性

• 描述: Carboprost tromethamine 是前列腺素 F2α (prostaglandin F2α) 的 15 甲基类似物。Carboprost tromethamine 能有效促进子宫规律性收缩,显著减少产后出血量。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
• 体内研究: 卡前列素氨丁三醇对预防剖宫产产后出血有显著作用,对改善高凝状态、维持血流动力学稳定有显著作用。卡前列素氨丁三醇治疗因子宫收缩乏力而持续出血的成功率为84-96%。
• 参考文献:

  [1]. Ling Z, et al. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262.

  [2]. Bai J, et al. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. Epub 2013 Nov 1.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UK8026000 CAS REGISTRY NUMBER : 58551-69-2 LAST UPDATED : 198910 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C21-H36-O5.C4-H11-N-O3 MOLECULAR WEIGHT : 489.73 WISWESSER LINE NOTATION : L5TJ AQ B2U4VQ C1U1XQ5&1 DQ &Q1XZ1Q1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 131 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 30 ug/kg SEX/DURATION : female 14 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,533,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 87 ug/kg SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 87 ug/kg SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Fertility - abortion Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 6 mg/kg SEX/DURATION : male 3 day(s) pre-mating female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 300 ug/kg SEX/DURATION : female 9-11 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

安全

• 危险品运输编码: NONH for all modes of transport