3471-05-4

• 常用中文名：Anabaseine
• 常用英文名：Anabase
• CAS号：3471-05-4
• 分子式：C₁₀H₁₂N₂
• 分子量：160.22
• 相关类别： 信号通路 跨膜转运 胆碱受体
• 发布时间：2016-05-25 22:00:03
• 更新时间：2024-01-10 18:53:12
• Anabaseine是一种生物碱,可刺激多种动物烟碱乙酰胆碱受体(ACHR),尤其是神经肌肉受体和α7 ACHR[1]。

名称

• 英文名: 3-(2,3,4,5-tetrahydropyridin-6-yl)pyridine
• 英文别名: anabaseine dihydrochloride; 2,3'-BIPYRIDINE,3,4,5,6-TETRAHYDRO; Anabaseine; 3,4,5,6-tetrahydro-2,3'-bipyridine

物化性质

• 密度: 1.09g/cm3
• 沸点: 263.9ºC at 760mmHg
• 分子式: C₁₀H₁₂N₂
• 分子量: 160.22
• 闪点: 113.4ºC
• 精确质量: 160.10000
• PSA: 25.25000
• LogP: 1.49020
• 折射率: 1.596

生物活性

• 描述: Anabaseine是一种生物碱,可刺激多种动物烟碱乙酰胆碱受体(ACHR),尤其是神经肌肉受体和α7 ACHR[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 神经疾病
• 体外研究: anabaseine(3.6μmol/kg；皮下注射)对乙酰胆碱、多巴胺和去甲肾上腺素的峰值效应值分别为50%、85%、62%[1][2]。anabaseine作为神经肌肉激动剂作用于青蛙腹直肌,EC50为0.25-0.74μM[1]。
• 参考文献:

  [1]. [1] Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273.

  [2]. [2] Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74(2):139-46.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DW1890000 CHEMICAL NAME : 2,3'-Bipyridine, 3,4,5,6-tetrahydro- CAS REGISTRY NUMBER : 3471-05-4 BEILSTEIN REFERENCE NO. : 0125981 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C10-H12-N2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,684,1976

安全

• 海关编码: 2933399090

合成路线

81417-95-0 ~74% 3471-05-4

文献：Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M. Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940

60573-68-4 ~% 3471-05-4

文献：Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M. Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940

614-18-6 161564-43-8 ~% 3471-05-4

文献：Shevchenko, Nikolay E.; Vlasov, Katja; Nenajdenko, Valentine G.; Roeschenthaler, Gerd-Volker Tetrahedron, 2011 , vol. 67, # 1 p. 69 - 74

626-55-1 ~% 3471-05-4

文献：Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

675-20-7 ~% 3471-05-4

文献：Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

85908-96-9 ~% 3471-05-4

文献：Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

614-18-6 4252-56-6 141-52-6 71-43-2 ~% 详细

文献：Spaeth; Mamoli Chemische Berichte, 1936 , vol. 69, p. 757,760 Full Text Show Details Duffield et al. Journal of the American Chemical Society, 1965 , vol. 87, p. 2926,2027 Full Text Show Details Kamimura; Yamamoto Agricultural and Biological Chemistry, 1963 , vol. 27, p. 450,453

614-18-6 4252-56-6 ~% 3471-05-4

文献：Spaeth; Mamoli Chemische Berichte, 1936 , vol. 69, p. 1082,1085

上下游产品

上游产品  9
81417-95-0 60573-68-4 614-18-6 626-55-1
675-20-7 85908-96-9 4252-56-6 141-52-6
71-43-2
下游产品  2
581-50-0 13078-04-1

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%