6998-60-3

• 常用中文名：利福霉素
• 常用英文名：Rifamycin
• CAS号：6998-60-3
• 分子式：C₃₇H₄₇NO₁₂
• 分子量：697.77
• 相关类别： 原料药 抗生素类药物 利福霉素类药
• 发布时间：2018-02-04 08:00:00
• 更新时间：2024-01-02 23:55:35
• Rifamycin (Rifamycin SV) 属于安沙霉素抗生素家族,从地中海曲霉或其突变体的发酵中分离出来。Rifamycin 对革兰氏阳性菌和在较小程度上对革兰氏阴性菌具有广泛的抗生素活性。

名称

• 中文名: 利福霉素
• 英文名: rifamycin SV
• 英文别名: RIFAMYCIN SV; Acetic acid,((1,2-dihydro-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-9-yl)oxy)-,21-acetate,1,2,2-tripropylhydrazide; rifamycin-S; (12S,3E,5S,13E,15Z)-7t-acetoxy-15,6,9,9c,11t-pentahydroxy-5r-methoxy-12,4,6t,8c,10c,12t,16-heptamethyl-2-oxa-18-aza-1(2,7)-naphtho[2,1-b]furana-cyclooctadecaphane-3,13,15-triene-11,17-dione; O4-(tripropylhydrazinocarbonyl-methyl)-rifamycin; Rifamycin,4-O-(2-oxo-2-(tripropylhydrazino)ethyl); rifamycin-B tripropylhydrazide; Rifamycin-B-tripropyl-hydrazid

物化性质

• 熔点: 300° (dec 140°)
• 分子式: C₃₇H₄₇NO₁₂
• 分子量: 697.77
• 精确质量: 697.31000
• PSA: 201.31000
• LogP: 4.89210
• 储存条件: -20°C

生物活性

• 描述: Rifamycin (Rifamycin SV) 属于安沙霉素抗生素家族,从地中海曲霉或其突变体的发酵中分离出来。Rifamycin 对革兰氏阳性菌和在较小程度上对革兰氏阴性菌具有广泛的抗生素活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Floss HG, et al. Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev. 2005 Feb;105(2):621-32.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KD1922000 CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20 ,22-heptamethyl-, 21-acetate CAS REGISTRY NUMBER : 6998-60-3 LAST UPDATED : 199509 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C37-H47-N-O12 MOLECULAR WEIGHT : 697.85 WISWESSER LINE NOTATION : T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U MH&&&TJ DQ GQ IQ J1 M1 QO1 R1 SOV1 T1 UQ V HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 625 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5800 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 700 mg/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 500 mg/kg SEX/DURATION : female 2 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 900 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1800 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Mammary gland DOSE/DURATION : 6300 nmol/L/24H (Continuous) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 5,141,1980 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,951,1965

安全

• 海关编码: 2941903000

海关

海关编码	2941903000