上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：奥昔卡因
纯度：99.0%
规格：
联系人：徐经理
联系电话：13311869306

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Oxethazaine
纯度：98.0%
规格：5g/1g/1g/1g
联系人：李先生
联系电话：18916172912

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]Oxethazaine,≥99%
纯度：99.0%
规格：50mg/5g/1g/1ml
联系人：夏言
联系电话：18016376636

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：奥昔卡因
纯度：95.0%
规格：100mg/50mg/200mg/100g
联系人：阿拉丁
联系电话：400-620-6333

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126-27-2生产厂家

126-27-2价格

126-27-2

126-27-2结构式

常用中文名：奥昔卡因
常用英文名：Oxethazaine
CAS号：126-27-2
分子式：C₂₈H₄₁N₃O₃
分子量：467.643
相关类别：分析化学标准品法医和兽医标准品
发布时间：2018-08-08 19:13:57
更新时间：2024-01-02 19:09:37
Oxethazaine是一种局部麻醉剂,在防止酸诱导的食管疼痛。

化源商城直购

中文名	奥昔卡因
英文名	Oxethazaine
中文别名	2-双(N-甲基-N-苯基叔丁基-氨基甲酰甲基)氨基乙醇阿塞赛因
英文别名	2,2'-[(2-Hydroxyethyl)imino]bis[N-methyl-N-(2-methyl-1-phenyl-2-propanyl)acetamide] 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methylacetamide] Acetamide, 2,2'-[(2-hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methyl- N,N-Bis[N-methyl-N-phenyl-tert-butylacetamido]-b-hydroxyethylamine EINECS 204-780-5 2,2'-[(2-Hydroxyethyl)imino]bis[N-methyl-N-(2-methyl-1-phenylpropan-2-yl)acetamide] MFCD00079202 2-[2-hydroxyethyl-[2-[methyl-(2-methyl-1-phenylpropan-2-yl)amino]-2-oxoethyl]amino]-N-methyl-N-(2-methyl-1-phenylpropan-2-yl)acetamide oxethazine 2,2'-[(2-Hydroxyethyl)imino]bis[N(1,1-dimethyl-2-phenylethyl)-N-methylacetamide]

描述	Oxethazaine是一种局部麻醉剂,在防止酸诱导的食管疼痛。
相关类别	信号通路 >> 抗感染 >> HBV 研究领域 >> 神经疾病

密度	1.1±0.1 g/cm3
沸点	630.4±55.0 °C at 760 mmHg
熔点	104-105°C
分子式	C₂₈H₄₁N₃O₃
分子量	467.643
闪点	335.1±31.5 °C
精确质量	467.314789
PSA	64.09000
LogP	4.94
外观性状	白色粉末
蒸汽压	0.0±1.9 mmHg at 25°C
折射率	1.558
储存条件	2-8℃
水溶解性	<0.1 g/100 mL at 23 ºC
分子结构	1、摩尔折射率：137.83 2、摩尔体积（cm³/mol）：427.6 3、等张比容（90.2K）：1107.1 4、表面张力（dyne/cm）：44.9 5、极化率（10-24cm3）：54.64
计算化学	1.疏水参数计算参考值（XlogP）:3.8 2.氢键供体数量:1 3.氢键受体数量:4 4.可旋转化学键数量:12 5.互变异构体数量:无 6.拓扑分子极性表面积64.1 7.重原子数量:34 8.表面电荷:0 9.复杂度:585 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.熔点（℃）：104-105。

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name: Oxethazaine
CAS-No.: 126-27-2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances

Section2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 4)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Harmful if swallowed.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal wordWarning
Hazard statement(s)
H302Harmful if swallowed.
Precautionary statement(s) none
Supplemental Hazardnone
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R22Harmful if swallowed.
S-phrase(s)
S36Wear suitable protective clothing.
Other hazards - none

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
: 2-Hydroxyethyliminobis(N-[α,α-dimethylphenethyl]-N-methylacetamide)
Synonyms
Oxetacaine
Formula: C28H41N3O3 C28H41N3O3
Molecular Weight: 467,64 g/mol
ComponentConcentration
Oxetacaine
CAS-No.126-27-2-
EC-No.204-780-5

Section4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

Section5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

Section6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) AppearanceForm: solid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evaporation rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

Section10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
Other decomposition products - no data available

Section11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 1.000 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation.
IngestionHarmful if swallowed.
SkinMay be harmful if absorbed through skin. May cause skin irritation.
EyesMay cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: AC3325000

Section12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

Section13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

Section14. TRANSPORT INFORMATION
UN number
ADR/RID: -IMDG: -IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA:Not dangerous goods
Transport hazard class(es)
ADR/RID: -IMDG: -IATA: -
Packaging group
ADR/RID: -IMDG: -IATA: -
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available

SECTION 15 - REGULATORY INFORMATION
N/A

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3325000

CHEMICAL NAME :: Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(alpha,alpha-dimeth ylphenethyl)-N-methyl-

CAS REGISTRY NUMBER :: 126-27-2

BEILSTEIN REFERENCE NO. :: 2404063

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C28-H41-N3-O3

MOLECULAR WEIGHT :: 467.72

WISWESSER LINE NOTATION :: R1X1&1&N1&V1N2Q1VN1&X1&1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82267 No. of Facilities: 838 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 29119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82267 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1056 (estimated) No. of Female Employees: 490 (estimated)

符号	GHS07
信号词	Warning
危害声明	H302
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R22
安全声明 (欧洲)	S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	AC3325000

100-92-5

126-27-2

文献：Journal of Organic Chemistry, , vol. 26, p. 2378 - 2383

2293-55-2

141-43-5

126-27-2

文献：Journal of Organic Chemistry, , vol. 26, p. 2378 - 2383

26187-18-8

141-43-5

126-27-2

文献：US2780646 , ;

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