中文名 | 四咪唑 盐酸盐 |
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英文名 | Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, hydrochloride (1:1) |
中文别名 | 盐酸四咪唑 |
英文别名 |
mcn-jr 8299
levamisole hydrochloride Tetramisole HCl (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride levamisole HCl (±)-Tetramisole hydrochloride 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride orovermol EINECS 225-799-5 MFCD00005536 6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride (1:1) McN-JR 8299-11 anthelvet DL-Tetramisole hydrochloride citarin ripereol bayer9051 r8299 ripercol Concurat Tetramisole hydrochloride l-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, hydrochloride (1:1) Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride nilverm DL-6-Phenyl-2,3,5,6-tetrahydroimidazole[2,1-b]thiazole Hydrochloride nilverom Tetramisole (hydrochloride) |
沸点 | 344.4ºC at 760 mmHg |
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熔点 | 266-267ºC |
分子式 | C11H13ClN2S |
分子量 | 240.752 |
闪点 | 162.1ºC |
精确质量 | 240.048798 |
PSA | 40.90000 |
LogP | 2.32160 |
外观性状 | 白色至淡奶油色结晶粉末 |
储存条件 | 常温,避光,阴凉干燥处,密封保存 |
稳定性 | 常温常压下稳定,白色或微黄色针状结晶。无臭。昧苦。溶于水(21g/100ml,20℃)、甲醇、丙二醇,微溶于乙醇、氯仿、己烷和丙酮。有刺激性。 |
水溶解性 | 200 g/L (20 ºC) |
计算化学 | 1.疏水参数计算参考值(XlogP):无 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:1 5.互变异构体数量:无 6.拓扑分子极性表面积40.9 7.重原子数量:15 8.表面电荷:0 9.复杂度:246 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
更多 | 1. 性状:白色或微黄色针状结晶。无臭。昧苦 2. 密度(g/mL,25):不确定 3. 相对蒸汽密度(g/mL,空气=1):不确定 4. 熔点(ºC):266-267 5. 沸点(ºC,常压):不确定 6. 沸点(ºC,0.3 mmHg):不确定 7. 折射率(nD20):不确定 8. 闪点(°F):不确定 9. 比旋光度(º, C=1, 水):不确定 10. 自燃点或引燃温度(ºC):不确定 11. 蒸气压(kPa,25ºC):不确定 12. 饱和蒸气压(kPa,60ºC):不确定 13. 燃烧热(KJ/mol):不确定 14. 临界温度(ºC):不确定 15. 临界压力(KPa):不确定 16. 油水(辛醇/水)分配系数的对数值:不确定 17. 爆炸上限(%,V/V):不确定 18. 爆炸下限(%,V/V):不确定 19. 溶解性:溶于水(21g/100ml,20℃)、甲醇、丙二醇,微溶于乙醇、氯仿、己烷和丙酮 |
Synonym:DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; (+-)-2,3,5,6-Tetrahycro-6-phenylimidazo (2,1-b)thiazole monohydrochloride; Tatramisole; DL-Tetramisole hydrochloride; Tetramisol hydrochlorid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Harmful if swallowed.Toxic. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: Harmful if swallowed. The toxicological properties of this substance have not been fully investigated. Causes gastrointestinal tract irritation. Inhalation: The toxicological properties of this substance have not been fully investigated. Causes irritation of the mucous membrane and upper respiratory tract. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood. Storage: Keep containers tightly closed. Store in a cool, dry area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 5086-74-8: Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystals Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 266.00 - 267.00 deg C Autoignition Temperature: 500 deg C ( 932.00 deg F) Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: 210 g/l (20C) Specific Gravity/Density: Not available. Molecular Formula: C11H12N2S.HCl Molecular Weight: 240.76 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 5086-74-8: NJ5950000 LD50/LC50: CAS# 5086-74-8: Oral, mouse: LD50 = 210 mg/kg; Oral, rat: LD50 = 480 mg/kg. Oral, Human: TDLo=2 mg/kg Carcinogenicity: Tetramisole hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. Safety Phrases: S 28B After contact with skin, wash immediately with plenty of water and soap. S 38 In case of insufficient ventilation, wear suitable respiratory equipment. WGK (Water Danger/Protection) CAS# 5086-74-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 5086-74-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 5086-74-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
毒理学数据: 1、急性毒性:人体静脉TDLo: 2 mg/kg;大鼠口径LD50:480 mg/kg;大鼠皮下LD50:130mg/kg 大鼠静脉LD50:24 mg/kg;小鼠口径LD50:210 mg/kg;小鼠皮下LD50:84 mg/kg 小鼠静脉LD50:22 mg/kg;鸭口径LD50:22 mg/kg 生态学数据: 该物质对环境可能有危害,对水体应给予特别注意 CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
符号 |
GHS07 |
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信号词 | Warning |
危害声明 | H302-H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
个人防护装备 | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
危害码 (欧洲) | Xi:Irritant; |
风险声明 (欧洲) | R22;R36/37/38 |
安全声明 (欧洲) | S26-S36 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
RTECS号 | NJ5950000 |
海关编码 | 2934999090 |
~% 5086-74-8 |
文献:American Cyanamid Company Patent: US4087611 A1, 1978 ; Title/Abstract Full Text Show Details American Cyanamid Company Patent: US4090025 A1, 1978 ; |
~% 5086-74-8 |
文献:American Cyanamid Company Patent: US4090025 A1, 1978 ; |
~% 5086-74-8 |
文献:DSO "Pharmachim" Patent: US4179460 A1, 1979 ; |
上游产品 3 | |
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下游产品 0 |
海关编码 | 2934100090 |
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中文概述 | 2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |