19895-95-5

• 常用中文名：山奈酚3-O-beta-D-槐糖苷
• 常用英文名：Kaempferol 3-O-beta-sophoroside
• CAS号：19895-95-5
• 分子式：C₂₇H₃₀O₁₆
• 分子量：610.518
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-04-05 08:00:00
• 更新时间：2024-01-02 13:29:59
• Kaempferol 3-O-sophoroside,Kaempferol 的衍生物,分离于栽培山参 (Panax ginseng) 的叶子,具有抗炎活性。

名称

• 中文名: 山奈酚-3-O-β-D-槐糖苷
• 英文名: kaempferol 3-O-β-D-glucosyl-(1→2)-β-D-glucoside
• 中文别名: 山奈酚-3-O-Beta-D-槐糖苷; 山奈酚-3-O-Beta-D-槐糖苷,山奈酚-3-O-槐糖苷
• 英文别名: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside; Kaempferol-3-sophoroside; 4H-1-Benzopyran-4-one, 3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-; Kaempferol 3-O-sophoroside; Sophoraflavonoloside; K3S; 3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 995.0±65.0 °C at 760 mmHg
• 熔点: 194-198℃
• 分子式: C₂₇H₃₀O₁₆
• 分子量: 610.518
• 闪点: 329.3±27.8 °C
• 精确质量: 610.153381
• PSA: 269.43000
• LogP: -0.58
• 外观性状: 粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.764
• 储存条件: 室温，惰性气体

生物活性

• 描述: Kaempferol 3-O-sophoroside,Kaempferol 的衍生物,分离于栽培山参 (Panax ginseng) 的叶子,具有抗炎活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点:

  Kaempferol 3-O-sophoroside possesses barrier integrity activity, inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-κB expression and production of TNF-α, thereby endorsing its usefulness as therapy for vascular inflammatory diseases[1].

• 参考文献:

  [1]. Kim TH, et al. Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells. Inflamm Res. 2012 Mar;61(3):217-24.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ3068000 CHEMICAL NAME : 4H-1-Benzopyran-4-one, 3-((2-O-beta-D-glucopyranosyl-beta-diglucopyranosyl)o xy)-5,7- dihydroxy-2-(4-hydroxyphenyl)- CAS REGISTRY NUMBER : 19895-95-5 LAST UPDATED : 199206 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C27-H30-O16 MOLECULAR WEIGHT : 610.57 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 29,73,1990

安全

• 危害码 (欧洲): Xi

合成路线

132998-80-2 ~49% 19895-95-5

文献：Markham, Kenneth R.; Andersen, Oeyvind M. Phytochemistry (Elsevier), 1990 , vol. 29, # 12 p. 3919 - 3920

55136-76-0 ~% 19895-95-5

文献：Yoshida; Saito; Kadoya Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 97 - 107

87863-90-9 ~% 19895-95-5

文献：Chemical and Pharmaceutical Bulletin, , vol. 35, # 1 p. 97 - 107

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