91-81-6

• 常用中文名：曲吡那敏
• 常用英文名：Tripelennamine
• CAS号：91-81-6
• 分子式：C₁₆H₂₁N₃
• 分子量：255.35800
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-06-25 21:11:31
• 更新时间：2024-01-03 13:00:19
• Tripelenamine是一种乙二胺衍生物,是一种有效的组胺H1受体拮抗剂。Tripelenamine可减轻由组胺引起的机体过敏反应。Tripelenamine可用于研究鼻炎、结膜炎、过敏和过敏反应[1][2][3]。

名称

• 中文名: 曲吡那敏
• 英文名: N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
• 英文别名: Piribenzil; Tonaril; N-benzyl-N',N'-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine; Benzoxale; Tripelennamin; Pyribenzamine; Cizaron; N-benzyl-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine; Resistamine; tripelenamin; Tripelennamina; tripelennamine; Pyrinamine base

物化性质

• 密度: 1.0683 (rough estimate)
• 沸点: 185 - 190ºC at 1.7 mm Hg
• 熔点: 25°C
• 分子式: C₁₆H₂₁N₃
• 分子量: 255.35800
• 精确质量: 255.17400
• PSA: 19.37000
• LogP: 2.64980
• 外观性状: 油性液体
• 折射率: nD25 1.5759-1.5765

生物活性

• 描述: Tripelenamine是一种乙二胺衍生物,是一种有效的组胺H1受体拮抗剂。Tripelenamine可减轻由组胺引起的机体过敏反应。Tripelenamine可用于研究鼻炎、结膜炎、过敏和过敏反应[1][2][3]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 内分泌
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点:

  H1 Receptor

• 参考文献:

  [1]. Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92(4):1515-23.

  [2]. Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52.

  [3]. Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : US2800000 CHEMICAL NAME : Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)- CAS REGISTRY NUMBER : 91-81-6 BEILSTEIN REFERENCE NO. : 0227074 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C16-H21-N3 MOLECULAR WEIGHT : 255.40 WISWESSER LINE NOTATION : T6NJ BN1R&2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 152 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 64 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 61 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Liver DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74620 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated)

合成路线

872298-31-2 124-40-3 ~75% 91-81-6

文献：Hamid, M. Haniti S. A.; Allen, C. Liana; Lamb, Gareth W.; Maxwell, Aoife C.; Maytum, Hannah C.; et al. Journal of the American Chemical Society, 2009 , vol. 131, p. 1766 - 1774

23826-72-4 ~% 91-81-6

文献：Gogate, Priyanka N.; Ethirajan, Manivannan; Kurenova, Elena V.; Magis, Andrew T.; Pandey, Ravindra K.; Cance, William G. European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 154 - 156

109-09-1 ~% 91-81-6

文献：Gogate, Priyanka N.; Ethirajan, Manivannan; Kurenova, Elena V.; Magis, Andrew T.; Pandey, Ravindra K.; Cance, William G. European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 154 - 156

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