盐酸吐根酚碱

• 常用名: 盐酸吐根酚碱
• 英文名: Cephaeline dihydrochloride
• CAS号: 3738-70-3
• 分子量: 539.534
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₄₀Cl₂N₂O₄
• 熔点: N/A
• 闪点: N/A

盐酸吐根酚碱用途

盐酸头孢菌素((-)-盐酸头孢菌素)是印度吐根中的一种酚性生物碱。盐酸头孢喹对寨卡病毒(ZIKV)和埃博拉病毒(EBOV)感染均具有有效的抑制作用[1][2]。

盐酸吐根酚碱名称

• 中文名: 盐酸吐根酚碱
• 英文名: cephaeline hydrochloride
• 中文别名: 吐根酚碱盐酸盐(七水)

盐酸吐根酚碱生物活性

• 描述: 盐酸头孢菌素((-)-盐酸头孢菌素)是印度吐根中的一种酚性生物碱。盐酸头孢喹对寨卡病毒(ZIKV)和埃博拉病毒(EBOV)感染均具有有效的抑制作用[1][2]。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 丝状病毒
• 参考文献:

  [1]. N.P.Sahu, et al. Determination of emetine and cephaeline in Ipecac roots by high- performance liquid chromatography. Journal of Chromatography A. 1982 Apr; 238( 2):525-529.

  [2]. Yang S, et al. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 2018 Jun 5;4:31.

盐酸吐根酚碱物理化学性质

• 分子式: C₂₈H₄₀Cl₂N₂O₄
• 分子量: 539.534
• 精确质量: 538.236511
• PSA: 63.19000
• LogP: 6.51110
• 储存条件: 2-8C

盐酸吐根酚碱英文别名

• 10,11,7'-Trimethoxy-emetan-6'-ol,Hydrochlorid
• AC1NUT82
• CHEBI:2535
• (2R,3R,11bS)-(+)-2-(3,4-dihydro-6-hydroxy-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-8-hydroxy-9,10-dimethoxy-2H-benzo[a]quinolizine (alangicine)
• Alangicine
• 7',10,11-Trimethoxyemetan-6'-ol dihydrochloride
• 2-(6-hydroxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-8-ol
• Cephaeline dihydrochloride
• 10,11,7'-trimethoxy-emet-1'-ene-9,6'-diol
• Emetan-6'-ol, 7',10,11-trimethoxy-, dihydrochloride (9CI)
• 10,11,7'-trimethoxy-emetan-6'-ol,dihydrochloride
• (2R,3R,11bS)-3-ethyl-2-(6-hydroxy-7-methoxy-3,4-dihydroisoquinolin-1-ylmethyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-8-ol
• 6-Isoquinolinol, 1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-, (1R)-, hydrochloride (1:2)
• 10,11,7'-Trimethoxy-emetan-6'-ol,Dihydrochlorid
• Emetan-6'-ol, 7',10,11-trimethoxy-, dihydrochloride