COX-2/5-LOX-IN-1

Modify Date: 2024-01-05 17:35:46

COX-2/5-LOX-IN-1 Structure
COX-2/5-LOX-IN-1 structure
Common Name COX-2/5-LOX-IN-1
CAS Number 2410384-50-6 Molecular Weight 383.83
Density N/A Boiling Point N/A
Molecular Formula C14H10ClN3O4S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of COX-2/5-LOX-IN-1


COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively[1].

 Names

Name COX-2/5-LOX-IN-1

 COX-2/5-LOX-IN-1 Biological Activity

Description COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively[1].
Related Catalog
References

[1]. Gedawy EM, et al. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur J Med Chem. 2020;189:112066.

 Chemical & Physical Properties

Molecular Formula C14H10ClN3O4S2
Molecular Weight 383.83